E-mail:  lrcgk8889@163.com
Education and Professinal Appointments:
2019.6 - Present: Associate Professor, Kunming Institute of Zoology, Chinese Academy of Sciences
2019.2 - 2019.5: Research Assistant, Kunming Institute of Zoology, the Chinese Academy of Sciences
2015.9 - 2019.1: Ph.D. candidate, Kunming Institute of Zoology, Chinese Academy of Sciences
2014.8 - 2015.8: Visiting student, Kunming Institute of Zoology, Chinese Academy of Sciences
2013.2 - 2014.7: Visiting student, Institute of Zoology, Chinese Academy of Sciences
2012.9 - 2015.6: M.S, School of Life Sciences, Lanzhou University
2008.9 - 2012.7: B.A, College of Animal Science and Technology, Northwest A&F University
First author (#) and Corresponding author (*):
1. Luo R#,*, Fan Y#, Yang J, Ye M, Zhang DF, Guo K, Li X, Bi R, Xu M, Yang LX, Li Y, Ran X, Jiang HY, Zhang C, Tan L, Sheng N, Yao YG*. 2021. 
   A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function and facilitates amyloid-β pathology and cognitive decline. 
   Signal Transduction and Targeted Therapy; 6(1):325.
2. Luo R#, Su L-Y#, Li G, Yang J, Liu Q, Yang L-X, Zhang D-F, Zhou H, Xu M, Fan Y, Li J, Yao Y-G*. 2020. 
   Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. 
   Autophagy; 16(1): 52–69 (Cover story).
3. Su L-Y#, Luo R#, Liu Q, Su J-R, Yang L-X, Ding Y-Q, Xu L*, Yao Y-G*. 2017. 
   Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine. 
   Autophagy; 13(9):1496-1511 (Cover story).
4. Luo R#, Shao X#, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li Y-X, Chang C, Qiao J, Peng C*, Wang Y-L*. 2014. 
   MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1.
   Hypertension; 64(4):839-45. 
5. Luo R#, Wang Y#, Xu P#, Cao G, Zhao Y, Shao X, Li Y-X, Chang C, Peng C, Wang Y-L*. 2016. 
   Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. 
   Scientific Reports; 6:19588.
6. Chen C, Liu JW, Huang KP, Xiong F, Ma YH, Guo LL, Ran XQ, Guo YR, Yao YG, Hao XJ*, Luo RC*, Zhang Y*. 2022. 
   Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylation. 
   Phytochemistry. https://doi.org/10.1016/j.phytochem.2022.113392.
7. Pu XX#, Ran XQ#, Yan Y#, Lu QY, Li JC, Li YY, Guan SP, Cao MM, Liu J, Hao XJ, Luo RC*, Di YT*. 2022. 
   Three new Jatrophane diterpenoids with bioactivity of inhibiting autophagic flux from Euphorbia peplus Linn. 
   Phytochemistry Letters. 50: 141-146.
8. Peng XR#, Luo RC#, Su HG, Zhou L, Ran XQ, Guo YR, Yao YG*, Qiu MH*. 2022. 
   (±)-Spiroganoapplanin A, a pair of meroterpenoid dimer with a complex polycyclic system from Ganoderma applanatum displaying the potential against Alzheimer’s disease. 
   Organic Chemistry Frontiers; 9: 3093-3101. 
9. Liu S#, Zhang CS#, Ran XQ#, Tang XH, Guo YR, Yan Y, Yao YG, Hao XJ, Luo RC*, Di YT*. 2021. 
   Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr. 
   Organic & Biomolecular Chemistry, 19: 9637-9640. 
10. Tang XH#, Luo RC#, Ye MS; Tang HY, Ma YL, Chen YN, Wang XM, Lu QY; Liu S, Li XN; Yan Y; Yang J, Ran XQ, Fang X, Yao YG*, Di YT*; Hao XJ*. 2021. 
    Harpertrioate A, an A,B,D-seco limonoid, with Promising Biological Ac-tivity Against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr. 
    Organic Letters; 23 (2), pp.262-267 (Cover story).
11. Fan Y#, Luo R#, Su L-Y, Xiang Q, Yu D, Xu L, Chen J-Q, Bi R, Wu D-D, Zheng P*, Yao Y-G*. 2018. 
    Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer's disease Research? 
    Journal of Alzheimer's Disease; 61:1015-1028.
12. Luo R, Chang C. 2014.
    Study on Spermatogonial Stem Cells in Tree Shrew Models. 
    Journal of Medical Molecular Biology, 11: 109-113 (Review).

1. Jiao L#, Su LY#, Liu Q#, Luo R, Qiao X, Xie T, Yang LX, Chen C, Yong-Gang Yao YG. 2022. 
   GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson's disease. 
   Free Radical Biology and Medicine, 189:111-121. 
2. Li YY, Yang Y, Sun M, Lu QY, Pu XX, Ran X, Li DM, Wan JJ, Huang JY, Guan SP, Luo R, Cheng YY*, Di YT*, Hao XJ. 2022.
   Jatrophane polyesters from Leaves of Euphorbia peplus with potential anti-inflammatory activity. 
   Phytochemistry Letters, 49: 114-119. 
3. Ai JQ, Luo R, Tu T*, Yang C, Jiang J, Zhang B, Bi R, Tu E, Yao YG, and Yan XX*. 2021. 
   Doublecortin-expressing neuronsin Chinese Tree Shrew forebrain exhibit mixed rodentand primate-like topographic characteristics. 
   Frontiers in Neuroanatomy, 15:727883.
4. Klionsky DJ,...Luo R... Zwerschke W. 2021. 
   Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)?. 
   Autophagy, 17(1):1-382.
5. Liu Q#, Su L-Y#,*, Sun C, Jiao L, Miao Y, Xu M,Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, Yao Y-G*. 2020. 
   Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. 
   Redox Biology, 34: 101560. 
6. Zhang J, Luo R, Man X-Y, Lv L-B, Yao Y-G*, Zheng M*. 2020. 
   The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin. 
   Zoological Research, 41(2): 208-212.
7. Zhang D-F#, Fan Y#, Xu M#, Wang G, WangD, Li J, Kong L-L, Zhou H, Luo R, Bi R, Wu Y, Li G-D, Alzheimer's Disease Neuroimaging Initiative (ADNI), 
   Li M, Luo X-J, Jiang H-Y, Tan L, Zhong C, Fang Y, Zhang C, Sheng N, Jiang T, Yao Y-G*. 
   Complement C7 is a novel risk gene for Alzheimer’s 1 disease in Han Chinese. 2022.
   National Science Review, 6: 257-274.
8. Wang H#, Zhao Y#, Luo R, Bian X, Wang Y, Shao X, Li YX, Liu M, Wang YL. 2020. 
   A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in troph. oblast syncytiolization: implication of trophoblast malfunction in preeclampsia. 
   Biology of Reproduction. 102(3):560-570.
9. Xu M#, Zhang D-F#*, Luo R, Wu Y, Zhou H, Kong L-L, Bi R, Yao Y-G*. 2018. 
   A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease. 
   Alzheimers & Dementia, 14(2):215-229.
10. Li G-D, Bi R, Zhang D-F, Xu M, Luo R, Wang D; Alzheimer's Disease Neuroimaging Initiative (ADNI), Fang Y, Li T, Zhang C, Yao Y-G*. 2017. 
    Female-specific effect of the BDNF gene on Alzheimer's disease. 
    Neurobiology of Aging, 53:192.e11-192.e19.
11. Liu M, Luo R, Wang H, Cao G, Wang Y-L*. 2017. 
    Recovery of fertility in quinestrol- or diethylstilbestrol (DES)-treated mice: implications for rodent management. 
    Integrative Zoology, 12(3):250-259.
12. Su L-Y#, Li H#, Lv L#, Feng Y-M, Li G-D, Luo R, Zhou H-J, Lei X-G, Ma L, Li JL, Xu L, Hu X-T*, Yao Y-G*. 2015. 
    Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/a-synuclein aggregation. 
    Autophagy, 11(10):1745-59.
Patent Application:
1. 姚永刚,罗荣灿,李桂瑜,苏凌燕,阳静,张登峰. 吉非罗齐及其衍生物用于治疗和/或预防神经退行性疾病的用途,2018.11,中国,申请号201811241909.0. 
2. 姚永刚,罗荣灿,李桂瑜,苏凌燕,阳静,张登峰. 匹立尼酸及其衍生物用于治疗和/或预防神经退行性疾病的用途,2018.11,中国,申请号201811241897.1. 
3. 姚永刚,罗荣灿,李桂瑜,苏凌燕,阳静,张登峰. 吉非罗齐及其衍生物用于治疗和/或预防神经退行性疾病的用途,2019.9,申请号PCT/CN2019/106476
4. 郝小江,姚永刚,邸迎彤,罗荣灿,唐小涵. 用于治疗和/或预防阿尔茨海默病药物牛筋果三内酯A的制备方法与应用, 2020.12,中国,专利号202011432002. X,(已授权)
5. 张于,罗荣灿,郝小江,姚永刚. 吲哚生物碱类化合物及其制备方法和其药物组合物与应用,2021.12,中国,申请号202210007290.7
6. 彭惺蓉,罗荣灿,邱明华,姚永刚,苏海国,冉晓倩,胡贵林,郭亚蓉,李忠荣,周 琳. (+/?)-sproganoapplanain A及其药物组合物与应用,2022.4,中国,申请号202210317429.8
7. 彭惺蓉,罗荣灿,邱明华,姚永刚,冉晓倩,胡贵林,郭亚蓉,李忠荣,周 琳. Ganoapplin A和ganoapplin B及其药物组合物和应用,2022.8,申请号202210994135.9
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