| Basic information |
| Official Symbol | RTN2 |
| Description | reticulon 2 |
| Other Aliases | NSP2, NSPL1, NSPLI, SPG12 |
| Other Description | NSP-like protein 1; NSP-like protein I; neuroendocrine-specific protein-like I; reticulon-2 |
| Mutation type | Insert and frame-shift 287-288:Y-K^A, Insert and frame-shift 311-312:T-P^G, premature termination 279:K->TAG |
| Location | Scaffold000067_1:3373978 3360180 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| RTN2 |
CAGGTCCTGCCGGTCTTCGCCCACTGCAAAGAAGCTCCGTCTACAGCCTC ATCTACCCCTGACTCTACAGAAGGAGGTAATGACGACTCCGATTTTCGGG AGCTGCACACAGCCCGGGAATTCTCTGAGGACGACGAGGAGGAGACTACG TCGCAGGACTGGGGCACCCCCCGGGAGCTGACGTTCTCCTATATAGCCTT CGATGGCATAGTGGGCTCTGGGGGCCGCAGGGATTCAGCTGCCCGTCGCC CTCGGCCCCAGGGCCGCTCAGTGTCGGAACCGCGAGACCTGCCCCCTCAG CCAGGATTGGGCGACAGTTTGGAGAGCATCCCCAGCCTGAGCCAATCTCC GGAGCCTGGTCGCCGTGGTGACCCTGACTCCGCCCCTCTAACGGAGCACC CCGTGGAGGACCTGAGGCTCAGGCTGGATCAGCTGGGCTGGGCGGCCAGG GGAGTGGGTTCCGGAGAGGACTCTGCCACCAGCAGCTCCACTCCACTGGA AGACGAGGAGCCGGATGGATCAGAGGTGGGAGAGGCTGGGGCAGTTGTGC CAGAATTGGACCTACAACTGCGACTCGCTCAATCCTCGCGGCTTGAGATC TTGACTCCCCAGCCTAGCCTGTGTTCTGGAGCCCCCCAGGCCAGTACCCC GTCTCCACCCCGGTCCCGGGATTCGAACTCTGGACCTGACCACCCCGTGC TGGACGAAGAGGACGAGCCATGGGGGCAGCTGGAGTGGGAGCCAATCACG GCACAGTGCCTCAGTAGCACAGACCAATCAAAATTTACATTGGAGCCACA CTTTCTAGGTAAGGCACAGCCCTGGTCGTAGACATCACTGCTTTTGGCTG TTTACAAGACAGTTCCAATTTTGGAATTGTCCCCACCTCTGTGGACAGCC ATTGGTTGGGTACAAAGGGGACCCCCCCCTACACCATCCCTCCGGGTTCC ACTGGAGTGGGCAAAATCCCCCAGAAGCAGCGGTGTCCGCAACCTCTCAC TCGGAGCCGAGATGGGGAGTAAAGTGGCGGATCTGCTGTACTGGAAGGAC ACGAGGACATCAGGAGTGGTCTTCACAGGCCTCATGGTCTCCCTGCTCTG CCTCCTGCACTTTAGCATCGTGTCCGTGGCCGCCCACGTGGCTCTCTTGC TGCTCTGCGGCACCATCTCTCTCAGGGTTTACCGCAAAGTGCTGCAGGCC GTGCACCGGGGGGATGGAGCCAACCCCTTCCAGGCCTACCTGGATGTGGA CCTGACCCTGACTCGGGAGCAGACCGAACGTCTGTCCCATCAGATTGCCT CGCACGTGATCGCTGCGGCCACGCAGCTGCGCCATTTCTTCTTGGTAGAA GACCTCGTGGATTCCCTCAAGCTGGCCCTCCTCTTCTACATCTTGACCTT CGTGGGTGCCGTCTTCAATGGTTTGACTCTTCTCATTCTGGGAGTAATCG CTTTATTCACCGTCCCCCTGCTGTACCGGCAGCACCAGGCCCAGATCGAC CAGTATGTGGGGCTGGTGACCAATCAGTTGAGCCACATCAAAGCTAAGAT CCGATCTAAGATCCCAGGGACTGGAGCCCTTGCTTCTGCAGCAGCCGCAG TCTCTGGATCCAAAGCCAAAGCCGAA |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 545 | 3 | 545 | Insert and frame-shift 287-288:Y-K^A, Insert and frame-shift 311-312:T-P^G, Premature termination 279:K->TAG |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
GlnValLeuProValPheAlaHisCys{L} >>>> Target Intron 1 >>>> {
|||||||||||||||||||||||||||{|} 2902 bp {
GlnValLeuProValPheAlaHisCys{L}++ ++{
CAGGTCCTGCCGGTCTTCGCCCACTGC{A}gt ag{
ys}GluAlaProSerThrAlaSerSerThrProAspSerThrGlu{G} >>>> Targe
||}||||||||||||||||||||||||||||||||||||||||||{|}
ys}GluAlaProSerThrAlaSerSerThrProAspSerThrGlu{G}++
AA}GAAGCTCCGTCTACAGCCTCATCTACCCCTGACTCTACAGAA{G}gt
t Intron 2 >>>> {ly}GlyAsnAspAspSerAspPheArgGluLeuHisThrAla
106 bp {||}|||||||||||||||||||||||||||||||||||||||
++{ly}GlyAsnAspAspSerAspPheArgGluLeuHisThrAla
ag{GA}GGTAATGACGACTCCGATTTTCGGGAGCTGCACACAGCC
ArgGluPheSerGluGluAspGluGluGluThrThrSerGlnAspTrpGlyThrProArg
||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||
ArgGluPheSerGluAspAspGluGluGluThrThrSerGlnAspTrpGlyThrProArg
CGGGAATTCTCTGAGGACGACGAGGAGGAGACTACGTCGCAGGACTGGGGCACCCCCCGG
GluLeuThrPheSerTyrIleAlaPheAspGlyValValGlySerGlyGlyArgArgAsp
||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||
GluLeuThrPheSerTyrIleAlaPheAspGlyIleValGlySerGlyGlyArgArgAsp
GAGCTGACGTTCTCCTATATAGCCTTCGATGGCATAGTGGGCTCTGGGGGCCGCAGGGAT
SerThrAlaArgArgProArgProGlnGlyArgSerValSerGluProArgAspGlnHis
||| ||||||||||||||||||||||||||||||||||||||||||||||||
SerAlaAlaArgArgProArgProGlnGlyArgSerValSerGluProArgAspLeuPro
TCAGCTGCCCGTCGCCCTCGGCCCCAGGGCCGCTCAGTGTCGGAACCGCGAGACCTGCCC
ProGlnProSerLeuGlyAspSerLeuGluSerIleProSerLeuSerGlnSerProGlu
||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||
ProGlnProGlyLeuGlyAspSerLeuGluSerIleProSerLeuSerGlnSerProGlu
CCTCAGCCAGGATTGGGCGACAGTTTGGAGAGCATCCCCAGCCTGAGCCAATCTCCGGAG
ProGlyArgArgGlyAspProAspThrAlaProProSerGluArgProLeuGluAspLeu
|||||||||||||||||||||||| |||||| ||| ||| |||||||||
ProGlyArgArgGlyAspProAspSerAlaProLeuThrGluHisProValGluAspLeu
CCTGGTCGCCGTGGTGACCCTGACTCCGCCCCTCTAACGGAGCACCCCGTGGAGGACCTG
ArgLeuArgLeuAspHisLeuGlyTrpValAlaArgGlyThrGlySerGlyGluAspSer
||||||||||||||| ||||||||| ||||||||| ||||||||||||||||||
ArgLeuArgLeuAspGlnLeuGlyTrpAlaAlaArgGlyValGlySerGlyGluAspSer
AGGCTCAGGCTGGATCAGCTGGGCTGGGCGGCCAGGGGAGTGGGTTCCGGAGAGGACTCT
SerThrSerSerSerThrProLeuGluAspGluGluProGlnGluProAsnArgLeuGlu
|||||||||||||||||||||||||||||||||||| |||
AlaThrSerSerSerThrProLeuGluAspGluGluProAspGlySerGluValGlyGlu
GCCACCAGCAGCTCCACTCCACTGGAAGACGAGGAGCCGGATGGATCAGAGGTGGGAGAG
ThrGlyGlu{A} >>>> Target Intron 3 >>>> {la}GlyGluGluLeuAsp
||| { } 96 bp { } |||||||||
AlaGlyAla{V}++ --{al}ValProGluLeuAsp
GCTGGGGCA{G}gt ta{TT}GTGCCAGAATTGGAC
LeuArgLeuArgLeuAlaGlnProSerSerProGluValLeuThrProGlnLeuSerPro
||| ||||||||||||||| ||| ||| |||||||||||| |||
LeuGlnLeuArgLeuAlaGlnSerSerArgLeuGluIleLeuThrProGlnProSerLeu
CTACAACTGCGACTCGCTCAATCCTCGCGGCTTGAGATCTTGACTCCCCAGCCTAGCCTG
GlySerGlyThrProGlnAlaGlyThrProSerProSerArgSerArgAspSerAsnSer
|||||| ||||||||| |||||||||||| |||||||||||||||||||||
CysSerGlyAlaProGlnAlaSerThrProSerProProArgSerArgAspSerAsnSer
TGTTCTGGAGCCCCCCAGGCCAGTACCCCGTCTCCACCCCGGTCCCGGGATTCGAACTCT
GlyProGluGluProLeuLeuGluGluGluGluLysGlnTrpGlyProLeuGluArgGlu
|||||| ||| ||| |||||| |||||| |||||| |||
GlyProAspHisProValLeuAspGluGluAspGluProTrpGlyGlnLeuGluTrpGlu
GGACCTGACCACCCCGTGCTGGACGAAGAGGACGAGCCATGGGGGCAGCTGGAGTGGGAG
ProValArgGlyGlnCysLeuAspSerThrAspGlnLeuGluPheThrValGluProArg
||| ||||||||| |||||||||||| |||||| ||||||
ProIleThrAlaGlnCysLeuSerSerThrAspGlnSerLysPheThrLeuGluProHis
CCAATCACGGCACAGTGCCTCAGTAGCACAGACCAATCAAAATTTACATTGGAGCCACAC
LeuLeuGlyThr >>>> Target Intron 4 >>>> AlaMetGluTrpLeuLysT
|||||| 739 bp ||| ||| |
PheLeuGlyLys-- ++AlaGlnProTrpSer***T
TTTCTAGGTAAGcc agGCACAGCCCTGGTCGTAGA
hrSerLeuLeuLeuAlaValTyr-LysThrValProIleLeuGluLeuSerProProLeu
|||||||||||||||||||||||#||||||||||||||||||||||||||||||||||||
hrSerLeuLeuLeuAlaValTyr#LysThrValProIleLeuGluLeuSerProProLeu
CATCACTGCTTTTGGCTGTTTACAAAGACAGTTCCAATTTTGGAATTGTCCCCACCTCTG
TrpThrAlaIleGlyTrpValGlnArgGlyProThr-ProProThrProValLeuArgVa
||||||||||||||||||||||||||||||||| #|||||||||||| ||||||||
TrpThrAlaIleGlyTrpValGlnArgGlyPro---#ProProThrProSerLeuArgVa
TGGACAGCCATTGGTTGGGTACAAAGGGGACCC---GCCCCCTACACCATCCCTCCGGGT
lLeuLeuLysTrpAlaLysSerProArgSerSerGlyValProSerLeuSerLeuGlyAl
| ||| |||||||||||||||||||||||||||||| ||||||||||||||
lProLeuGluTrpAlaLysSerProArgSerSerGlyValArgAsnLeuSerLeuGlyAl
TCCACTGGAGTGGGCAAAATCCCCCAGAAGCAGCGGTGTCCGCAACCTCTCACTCGGAGC
aAspMetGlySerLys{V} >>>> Target Intron 5 >>>> {al}AlaAspLe
| ||||||||||||{|} 5702 bp {||}||||||||
aGluMetGlySerLys{V}++ ++{al}AlaAspLe
CGAGATGGGGAGTAAA{G}gt ag{TG}GCGGATCT
uLeuTyrTrpLysAspThrArgThrSerGlyValValPheThrGlyLeuMetValSerLe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
uLeuTyrTrpLysAspThrArgThrSerGlyValValPheThrGlyLeuMetValSerLe
GCTGTACTGGAAGGACACGAGGACATCAGGAGTGGTCTTCACAGGCCTCATGGTCTCCCT
uLeuCysLeuLeuHisPheSerIleValSerValAlaAlaHisLeuAlaLeuLeuLeuLe
||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||
uLeuCysLeuLeuHisPheSerIleValSerValAlaAlaHisValAlaLeuLeuLeuLe
GCTCTGCCTCCTGCACTTTAGCATCGTGTCCGTGGCCGCCCACGTGGCTCTCTTGCTGCT
uCysGlyThrIleSerLeuArgValTyrArgLysValLeuGlnAlaValHisArgGlyAs
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
uCysGlyThrIleSerLeuArgValTyrArgLysValLeuGlnAlaValHisArgGlyAs
CTGCGGCACCATCTCTCTCAGGGTTTACCGCAAAGTGCTGCAGGCCGTGCACCGGGGGGA
pGlyAlaAsnProPhe{Gl} >>>> Target Intron 6 >>>> {n}AlaTyrLe
||||||||||||||||{||} 361 bp {|}||||||||
pGlyAlaAsnProPhe{Gl}++ ++{n}AlaTyrLe
TGGAGCCAACCCCTTC{CA}gt ag{G}GCCTACCT
uAspValAspLeuThrLeuThrArgGluGlnThrGluArgLeuSerHisGlnIleThrSe
||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||
uAspValAspLeuThrLeuThrArgGluGlnThrGluArgLeuSerHisGlnIleAlaSe
GGATGTGGACCTGACCCTGACTCGGGAGCAGACCGAACGTCTGTCCCATCAGATTGCCTC
rArgValValSerAlaAlaThrGlnLeuArgHisPhePheLeuValGluAspLeuValAs
| ||| |||||||||||||||||||||||||||||||||||||||||||||||
rHisValIleAlaAlaAlaThrGlnLeuArgHisPhePheLeuValGluAspLeuValAs
GCACGTGATCGCTGCGGCCACGCAGCTGCGCCATTTCTTCTTGGTAGAAGACCTCGTGGA
pSerLeuLys >>>> Target Intron 7 >>>> LeuAlaLeuLeuPheTyrIle
|||||||||| 136 bp |||||||||||||||||||||
pSerLeuLys++ ++LeuAlaLeuLeuPheTyrIle
TTCCCTCAAGgt agCTGGCCCTCCTCTTCTACATC
LeuThrPheValGlyAlaIlePheAsnGlyLeuThrLeuLeuIleLeu{G} >>>> Ta
|||||||||||||||||| |||||||||||||||||||||||||||{|}
LeuThrPheValGlyAlaValPheAsnGlyLeuThrLeuLeuIleLeu{G}++
TTGACCTTCGTGGGTGCCGTCTTCAATGGTTTGACTCTTCTCATTCTG{G}gt
rget Intron 8 >>>> {ly}ValIleGlyLeuPheThrIleProLeuLeuTyrArg
127 bp {||}|||||| ||||||||| |||||||||||||||
++{ly}ValIleAlaLeuPheThrValProLeuLeuTyrArg
ag{GA}GTAATCGCTTTATTCACCGTCCCCCTGCTGTACCGG
GlnHisGln >>>> Target Intron 9 >>>> AlaGlnIleAspGlnTyrValG
||||||||| 1747 bp ||||||||||||||||||||||
GlnHisGln++ ++AlaGlnIleAspGlnTyrValG
CAGCACCAGgt agGCCCAGATCGACCAGTATGTGG
lyLeuValThrAsnGlnLeuSerHisIleLysAla{Ly} >>>> Target Intron
|||||||||||||||||||||||||||||||||||{||} 255 bp
lyLeuValThrAsnGlnLeuSerHisIleLysAla{Ly}++
GGCTGGTGACCAATCAGTTGAGCCACATCAAAGCT{AA}gt
10 >>>> {s}IleArgAlaLysIleProGlyThrGlyAlaLeuAlaSerAlaAlaAla
{|}|||||| |||||||||||||||||||||||||||||||||||||||
++{s}IleArgSerLysIleProGlyThrGlyAlaLeuAlaSerAlaAlaAla
ag{G}ATCCGATCTAAGATCCCAGGGACTGGAGCCCTTGCTTCTGCAGCAGCC
AlaValSerGlySerLysAlaLysAlaGlu
||||||||||||||||||||||||||||||
AlaValSerGlySerLysAlaLysAlaGlu
GCAGTCTCTGGATCCAAAGCCAAAGCCGAA
//
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