| Basic information |
| Official Symbol | PRR5-ARHGAP8 |
| Description | PRR5-ARHGAP8 readthrough |
| Other Aliases | NA |
| Other Description | PRR5-ARHGAP8 fusion; PRR5-ARHGAP8 fusion protein |
| Mutation type | Insert and frame-shift 601-602:G-L^C |
| Location | Scaffold143651_1:3281207 3150629 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| PRR5-ARHGAP8 |
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGA CTTGGGCAAGAGAGAGCCGGCCGCCGCCGCCGCGGACGAGCGAGGCACGC AGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGG GTGATCGCCGTCTTCCAGCGCAAAGGGTTGCCTGACCAGGAGCTCTTCAG CCTCAATGAGGGTGTCCGGCAGCTGCTGAAGACGGAGCTGGGGTCCTTCT TCACGGAGTACCTGCAGAACCAGCTGCTGACGAAAGGCATGGTGATTCTC CGGGACAAGATCCGCTTCTATGAGGGGCAGAAGCTGCTGGACTCACTGGC AGAAACCTGGGACTTCTTCTTCAGCGACGTGCTGCCCACGCTGCAGGCCG TCTTCTACCCCGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTG CTCCACTTCCGGAACACCATCACCCTCAGCGTGAAGCTGGAGGATGCACT GGCCCGCGCCCATGCCCGGGTGCCCCCCGCCATCGTGCAGATGCTGCTGG TGCTGCAGGGGGTACACGAGTCCCGGGGTGTGACTGAGGACTACCTGCGC CTAGAGACACTGATCCAGAAGGTGGTGTCGCCCTACCTGGGCACCTACGG CCTCTACTCCAGCGAGGGGCCCTTCACCCACTCCTGCATCCTGGAGCTGC AGAGAGACGAGGAAGAGGCAGCAGCACTGGGCAGAGTGAAAAGACCCTCG GTGGTGCACGTGACCGGCCAGGACCCTGCACTGACCACGAGTCACCCGTT CTATGACGTGGCCAGACACGGCATCCTGCAGGTGGCAGGGGTCGACCTCT TTGGAAGACGCGTCGTCACGTTCAGCTCCTGCAGGCTGCCCCCCTCCCAC CAGCTCAACCACCAGCGGCTCTTGGAGTACAGGAAGAACCTGAAGGCCCT GTACGTGGTGCACCCCACCAGCTTCGTCAAAGTCCTGTGGACCATCTTCA AGCCCCTCATCAGCCACAAGTTTGGGAAGAAAGTCACCTACTTCAACTCC CTGAGTGAGCTCCGTGAGCACCTGCCCTACGACCAGCTGGCTGTCCCCCC GGAGGTCGTGCGGTACCAAGAGCAGCTCCGGAGCCTTCACAGGGGCCAGC CACTCCCTCCTGCCAAGACGCCGCCGCCGCGGCCTCCTCTGCCCACCCAG CAGTTTGGCGTCAGCCTGCAATACCTCAAGGACAAGAATGGAGGCGAGCT CATCCCCCCTGTGCTGAGGTTCACGGTGACATACCTGCGCCAGAAAGGGC TTCGCACTGAGGGCCTGTTCCGGAGGTCGGCCAGTGTCCAGACCATCCAA GAGATCCAGAGGCTCTACAATCAGGGGAAGCCCGTGAACTTCGACGACTA CGGGGACATCCACGTCCCGGCCGTGACCCTGAAGACCTTCCTGCGGGAGC TGCCCCAGCCGCTGCTGACCTTCACAGCCTACGAGCAAATCCTCGAACTC ACCAGTGTGGAGAGCAGCCTGCGTGTGACCCACTGTCGCCAGATCCTGCA GAGCCTTCCAGAGCACAACTACGCCGTCCTGCGCTACCTCATGGACTTCC TGCACACGGTGTCCCGGGAGAGCCTTTTTAACAAAATGAACAGCTCCAAC CTGGCCTGTGTCTTCGGGCTGAATTTAATCTGGCCGTCCCAGGGGGTGGC CTCCCTCAGTGCCCTCGTGCCCCTGAACCTCTTCACTGAACTGCTGATCG AGTACTACGAGAGGGTCTTCAGCGCCCAGGAGGCCCCTGGACAGCAGGCC CTGGCACCATGGCTGCGGGTGAGCAGAGCGGCTCCTTCTCCGGAG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 643 | 1 | 616 | Insert and frame-shift 601-602:G-L^C |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetArgThrLeuArgArgLeuLysPheMetSerSerProSerLeuSerAspLeuGlyL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MetArgThrLeuArgArgLeuLysPheMetSerSerProSerLeuSerAspLeuGlyL
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACTTGGGCA
ysArgGluPro<->AlaAlaAlaAlaAspGluArgGlyThrGlnGlnArgArgAlaCy
||||||||||| ||||||||||||||||||||||||||||||||||||||||||||
ysArgGluProAlaAlaAlaAlaAlaAspGluArgGlyThrGlnGlnArgArgAlaCy
AGAGAGAGCCGGCCGCCGCCGCCGCGGACGAGCGAGGCACGCAGCAGCGCCGGGCCTG
sAlaAsnAlaThrTrpAsn{Se} >>>> Target Intron 1 >>>> {r}Ile
|||||||||||||||||||{||} 11014 bp {|}|||
sAlaAsnAlaThrTrpAsn{Se}++ ++{r}Ile
CGCCAACGCCACCTGGAAC{AG}gt ag{C}ATC
HisAsnGlyValIleAlaValPheGlnArgLysGlyLeuProAspGlnGluLeuPheS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HisAsnGlyValIleAlaValPheGlnArgLysGlyLeuProAspGlnGluLeuPheS
CACAACGGGGTGATCGCCGTCTTCCAGCGCAAAGGGTTGCCTGACCAGGAGCTCTTCA
erLeuAsnGluGlyVal{Ar} >>>> Target Intron 2 >>>> {g}GlnLe
|||||||||||||||||{||} 7086 bp {|}|||||
erLeuAsnGluGlyVal{Ar}++ ++{g}GlnLe
GCCTCAATGAGGGTGTC{CG}gt ag{G}CAGCT
uLeuLysThrGluLeuGlySerPhePheThrGluTyrLeuGln >>>> Target I
||||||||||||||||||||||||||||||||||||||||||| 1740
uLeuLysThrGluLeuGlySerPhePheThrGluTyrLeuGln++
GCTGAAGACGGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGgt
ntron 3 >>>> AsnGlnLeuLeuThrLysGlyMetValIleLeuArgAspLysIl
bp ||||||||||||||||||||||||||||||||||||||||||||
++AsnGlnLeuLeuThrLysGlyMetValIleLeuArgAspLysIl
agAACCAGCTGCTGACGAAAGGCATGGTGATTCTCCGGGACAAGAT
eArgPheTyrGlu{G} >>>> Target Intron 4 >>>> {ly}GlnLysLeu
|||||||||||||{|} 3316 bp {||}|||||||||
eArgPheTyrGlu{G}++ ++{ly}GlnLysLeu
CCGCTTCTATGAG{G}gt ag{GG}CAGAAGCTG
LeuAspSerLeuAlaGluThrTrpAspPhePhePheSerAspValLeuProMetLeuG
||||||||||||||||||||||||||||||||||||||||||||||||||| ||||
LeuAspSerLeuAlaGluThrTrpAspPhePhePheSerAspValLeuProThrLeuG
CTGGACTCACTGGCAGAAACCTGGGACTTCTTCTTCAGCGACGTGCTGCCCACGCTGC
lnAlaIlePheTyrProValGln >>>> Target Intron 5 >>>> GlyLys
||||| ||||||||||||||| 310 bp ||||||
lnAlaValPheTyrProValGln++ ++GlyLys
AGGCCGTCTTCTACCCCGTGCAGgt agGGCAAG
GluProSerValArgGlnLeuAlaLeuLeuHisPheArgAsnAlaIleThrLeuSerV
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||
GluProSerValArgGlnLeuAlaLeuLeuHisPheArgAsnThrIleThrLeuSerV
GAGCCATCGGTGCGCCAGCTGGCCCTGCTCCACTTCCGGAACACCATCACCCTCAGCG
alLysLeuGluAspAlaLeuAlaArgAlaHisAlaArgValProProAlaIleValGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
alLysLeuGluAspAlaLeuAlaArgAlaHisAlaArgValProProAlaIleValGl
TGAAGCTGGAGGATGCACTGGCCCGCGCCCATGCCCGGGTGCCCCCCGCCATCGTGCA
nMetLeuLeuValLeuGln >>>> Target Intron 6 >>>> GlyValHisG
||||||||||||||||||| 1672 bp ||||||||||
nMetLeuLeuValLeuGln++ ++GlyValHisG
GATGCTGCTGGTGCTGCAGgt agGGGGTACACG
luSerArgGlyValThrGluAspTyrLeuArgLeuGluThrLeuValGlnLysValVa
|||||||||||||||||||||||||||||||||||||||||||| |||||||||||
luSerArgGlyValThrGluAspTyrLeuArgLeuGluThrLeuIleGlnLysValVa
AGTCCCGGGGTGTGACTGAGGACTACCTGCGCCTAGAGACACTGATCCAGAAGGTGGT
lSerProTyrLeuGlyThrTyrGlyLeuHisSerSerGluGlyProPheThrHisSer
|||||||||||||||||||||||||||| |||||||||||||||||||||||||||
lSerProTyrLeuGlyThrTyrGlyLeuTyrSerSerGluGlyProPheThrHisSer
GTCGCCCTACCTGGGCACCTACGGCCTCTACTCCAGCGAGGGGCCCTTCACCCACTCC
CysIleLeu{G} >>>> Target Intron 7 >>>> {lu}LeuGlnArgAspL
|||||||||{|} 63860 bp {||}||||||||||||
CysIleLeu{G}++ ++{lu}LeuGlnArgAspG
TGCATCCTG{G}gt ag{AG}CTGCAGAGAGACG
ysAlaAlaAlaAlaAlaValLeuGlyAlaValArgLysArgProSerValValProMe
||||||||| |||||| ||| ||||||||||||||||||
luGluGluAlaAlaAla---LeuGlyArgVal---LysArgProSerValValHisVa
AGGAAGAGGCAGCAGCA---CTGGGCAGAGTG---AAAAGACCCTCGGTGGTGCACGT
tAlaGlyGlnAspProAlaLeuSerThrSerHisProPheTyrAspValAlaArgHis
|||||||||||||||||| |||||||||||||||||||||||||||||||||
lThrGlyGlnAspProAlaLeuThrThrSerHisProPheTyrAspValAlaArgHis
GACCGGCCAGGACCCTGCACTGACCACGAGTCACCCGTTCTATGACGTGGCCAGACAC
GlyIleLeuGlnValAla{G} >>>> Target Intron 8 >>>> {ly}AspA
||||||||||||||||||{|} 3533 bp {||} |
GlyIleLeuGlnValAla{G}++ ++{ly}ValA
GGCATCCTGCAGGTGGCA{G}gt ag{GG}GTCG
spArgPheGlyArgArgValValThrPheSerCysCysArgMetProProSerHisGl
|| ||||||||||||||||||||||||||| |||||| ||||||||||||
spLeuPheGlyArgArgValValThrPheSerSerCysArgLeuProProSerHisGl
ACCTCTTTGGAAGACGCGTCGTCACGTTCAGCTCCTGCAGGCTGCCCCCCTCCCACCA
uLeuAspHisGlnArgLeuLeu{Gl} >>>> Target Intron 9 >>>> {u}
||| |||||||||||||||{||} 5289 bp {|}
nLeuAsnHisGlnArgLeuLeu{Gl}++ ++{u}
GCTCAACCACCAGCGGCTCTTG{GA}gt ag{G}
TyrLysLysAsnLeuLysAlaLeuTyrValValHisProThrSerPheIleLysValL
||| |||||||||||||||||||||||||||||||||||||||||| |||||||
TyrArgLysAsnLeuLysAlaLeuTyrValValHisProThrSerPheValLysValL
TACAGGAAGAACCTGAAGGCCCTGTACGTGGTGCACCCCACCAGCTTCGTCAAAGTCC
euTrpAsnIleLeuLysProLeuIle{Se} >>>> Target Intron 10 >>>>
||||| ||| ||||||||||||{||} 8223 bp
euTrpThrIlePheLysProLeuIle{Se}++
TGTGGACCATCTTCAAGCCCCTCATC{AG}gt
{r}HisLysPheGlyLysLysValIleTyrPheAsnTyrLeuSerGluLeuHisGl
{|}||||||||||||||||||||| ||||||||| |||||||||||| ||
++{r}HisLysPheGlyLysLysValThrTyrPheAsnSerLeuSerGluLeuArgGl
ag{C}CACAAGTTTGGGAAGAAAGTCACCTACTTCAACTCCCTGAGTGAGCTCCGTGA
uHisLeuLysTyrAspGlnLeuValIleProProGluValLeu{Ar} >>>> Targ
||||||| |||||||||||| |||||||||||| {||}
uHisLeuProTyrAspGlnLeuAlaValProProGluValVal{Ar}++
GCACCTGCCCTACGACCAGCTGGCTGTCCCCCCGGAGGTCGTG{CG}gt
et Intron 11 >>>> {g}TyrAspGluLysLeuGlnSerLeuHisGluGlyArg
3732 bp {|}||| ||| ||| ||||||||| |||
++{g}TyrGlnGluGlnLeuArgSerLeuHisArgGlyGln
ag{G}TACCAAGAGCAGCTCCGGAGCCTTCACAGGGGCCAG
ThrProProProThrLysThrProProProArgProProLeuProThrGlnGlnPheG
|||||| |||||||||||||||||||||||||||||||||||||||||||
ProLeuProProAlaLysThrProProProArgProProLeuProThrGlnGlnPheG
CCACTCCCTCCTGCCAAGACGCCGCCGCCGCGGCCTCCTCTGCCCACCCAGCAGTTTG
lyValSerLeuGln{Ty} >>>> Target Intron 12 >>>> {r}LeuLysA
||||||||||||||{||} 11214 bp {|}|||||||
lyValSerLeuGln{Ty}++ ++{r}LeuLysA
GCGTCAGCCTGCAA{TA}gt ag{C}CTCAAGG
spLysAsnGlnGlyGluLeuIleProProValLeuArgPheThrValThrTyrLeuAr
|||||||| |||||||||||||||||||||||||||||||||||||||||||||||
spLysAsnGlyGlyGluLeuIleProProValLeuArgPheThrValThrTyrLeuAr
ACAAGAATGGAGGCGAGCTCATCCCCCCTGTGCTGAGGTTCACGGTGACATACCTGCG
gGluLys{G} >>>> Target Intron 13 >>>> {ly}LeuArgThrGluGl
| |||{|} 1759 bp {||}||||||||||||||
gGlnLys{G}++ ++{ly}LeuArgThrGluGl
CCAGAAA{G}gt ag{GG}CTTCGCACTGAGGG
yLeuPheArgArgSerAlaSerValGlnThrValArgGluIleGlnArgLeuTyrAsn
||||||||||||||||||||||||||||||| |||||||||||||||||||||
yLeuPheArgArgSerAlaSerValGlnThrIleGlnGluIleGlnArgLeuTyrAsn
CCTGTTCCGGAGGTCGGCCAGTGTCCAGACCATCCAAGAGATCCAGAGGCTCTACAAT
Gln{G} >>>> Target Intron 14 >>>> {ly}LysProValAsnPheAsp
|||{|} 1333 bp {||}||||||||||||||||||
Gln{G}++ ++{ly}LysProValAsnPheAsp
CAG{G}gt ag{GG}AAGCCCGTGAACTTCGAC
AspTyrGlyAspIleHisIleProAlaValIleLeuLysThrPheLeuArgGluLeuP
|||||||||||||||||| ||||||||| |||||||||||||||||||||||||
AspTyrGlyAspIleHisValProAlaValThrLeuLysThrPheLeuArgGluLeuP
GACTACGGGGACATCCACGTCCCGGCCGTGACCCTGAAGACCTTCCTGCGGGAGCTGC
roGlnProLeuLeuThrPheGlnAlaTyrGluGlnIleLeuGlyIleThr{C} >>>
|||||||||||||||||||| |||||||||||||||||| |||{ }
roGlnProLeuLeuThrPheThrAlaTyrGluGlnIleLeuGluLeuThr{S}++
CCCAGCCGCTGCTGACCTTCACAGCCTACGAGCAAATCCTCGAACTCACC{A}gt
> Target Intron 15 >>>> {ys}ValGluSerSerLeuArgValThrGlyCy
2935 bp { }|||||||||||||||||||||||| ||
++{er}ValGluSerSerLeuArgValThrHisCy
ag{GT}GTGGAGAGCAGCCTGCGTGTGACCCACTG
sArgGlnIleLeuArgSerLeuProGluHisAsnTyrValValLeuArgTyrLeuMet
||||||||||||| ||||||||||||||||||||| ||||||||||||||||||
sArgGlnIleLeuGlnSerLeuProGluHisAsnTyrAlaValLeuArgTyrLeuMet
TCGCCAGATCCTGCAGAGCCTTCCAGAGCACAACTACGCCGTCCTGCGCTACCTCATG
GlyPheLeuHisAla >>>> Target Intron 16 >>>> ValSerArgGluS
||||||||| 1717 bp |||||||||||||
AspPheLeuHisThr++ ++ValSerArgGluS
GACTTCCTGCACACGgt agGTGTCCCGGGAGA
erIlePheAsnLysMetAsnSerSerAsnLeuAlaCysValPheGlyLeuAsnLeuIl
|| |||||||||||||||||||||||||||||||||||||||||||||||||||||
erLeuPheAsnLysMetAsnSerSerAsnLeuAlaCysValPheGlyLeuAsnLeuIl
GCCTTTTTAACAAAATGAACAGCTCCAACCTGGCCTGTGTCTTCGGGCTGAATTTAAT
eTrpProSerGlnGlyValSerSerLeuSerAlaLeuValProLeuAsnMetPheThr
||||||||||||||||||| ||||||||||||||||||||||||||| ||||||
eTrpProSerGlnGlyValAlaSerLeuSerAlaLeuValProLeuAsnLeuPheThr
CTGGCCGTCCCAGGGGGTGGCCTCCCTCAGTGCCCTCGTGCCCCTGAACCTCTTCACT
GluLeuLeuIleGluTyrTyrGluLysIlePheSerThrProGluAlaProGlyGluH
|||||||||||||||||||||||| |||||| ||||||||||||
GluLeuLeuIleGluTyrTyrGluArgValPheSerAlaGlnGluAlaProGlyGlnG
GAACTGCTGATCGAGTACTACGAGAGGGTCTTCAGCGCCCAGGAGGCCCCTGGACAGC
isGly-LeuAlaProTrpGluGlnGlySerArgAlaAlaProLeuGlnGlu
#|||||||||||| ||||||||||||||| |||
lnAla#LeuAlaProTrpLeuArgValSerArgAlaAlaProSerProGlu
AGGCCCCTGGCACCATGGCTGCGGGTGAGCAGAGCGGCTCCTTCTCCGGAG
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