| Basic information |
| Official Symbol | NOX1 |
| Description | NADPH oxidase 1 |
| Other Aliases | RP1-146H21.1, GP91-2, MOX1, NOH-1, NOH1 |
| Other Description | NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase homolog-1; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); mitogenic oxidase 1 |
| Mutation type | Insert and frame-shift 392-393:V-F^T |
| Location | Scaffold143746_1:153577 144819 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| NOX1 |
GTTCTCATGTGCCCATCCACAGTTTTGGAATTGCAGATGAATAAGTGTGG CTTCAGCATGGAAGTGGGGCAATATATCTTTGTTAATTGCCCCTTGATTT CTCTCCTGGAATGGCATCCCTTTACTCTGTCCCCTGCCCCAGAGGAAGAC TTCTCCATTCATATCAAAGCAGTGGGGGGCTGGTCAGAAAGTCTCATAAG GGCTTTTAAACAGCATTCATCAATTCTCAGCAGAATTGAAGTGGATGGCC CCTTAGGCACAGCCAGTGAGGATGTTTTCCAGTATATAGTAGCTATGCTG GTTGGAGTAGGAATTGGGGTCACCTCCTTTGCTTCCATTTTGAAATGCAT CTGGTACAAATTTCAGCATGCAAACCACAAGCTTAAAACAAGAAAAATCT ATTTCTACTGGATCTTCAGGGAGACAGGTGCTTTTGCCTGTTTCAGTGAA TTAATTACTTCTCTGGAACAGGAGATGGAGGAATTAGGCAAAACGAGTTT TCTAAACTTCCGTCTTTACCTCACCGGATGGGACAGCAACAATGCTGGTA ATGAAGCATTGAGCTTTGACAATCCCACTGACATCCTGACAGGTTTGAAA CAGCAAACCTCCTCAGGGAAACCAGTGTGGGAAAATGAGTATTCTACAAT AGCTACTGCCTACCCCAGGTCTGTGGTGGGAGTTTTCTTATGTGGTCCTT GGACTTTGGCAAAGAGTCTAAGCAAATGCTGTTACCGATACTTCAGTCTG GATCCTAGGAAGGTTCAATTCTACTTCAACAGGGAAAATTTC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 564 | 300 | 564 | Insert and frame-shift 392-393:V-F^T |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
ValValMetHisProSerLysValLeuGluLeuGlnMetAsnLysArgGlyPheSerMet
||| ||| |||||| |||||||||||||||||||||||| ||||||||||||
ValLeuMetCysProSerThrValLeuGluLeuGlnMetAsnLysCysGlyPheSerMet
GTTCTCATGTGCCCATCCACAGTTTTGGAATTGCAGATGAATAAGTGTGGCTTCAGCATG
GluValGlyGlnTyrIlePheValAsnCysProSerIleSerLeuLeuGluTrpHisPro
||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||
GluValGlyGlnTyrIlePheValAsnCysProLeuIleSerLeuLeuGluTrpHisPro
GAAGTGGGGCAATATATCTTTGTTAATTGCCCCTTGATTTCTCTCCTGGAATGGCATCCC
PheThrLeuThrSerAlaProGluGluAspPhePheSerIleHisIleArgAlaAlaGly
||||||||| ||||||||||||||| ||||||||||||||| ||| |||
PheThrLeuSerProAlaProGluGluAsp---PheSerIleHisIleLysAlaValGly
TTTACTCTGTCCCCTGCCCCAGAGGAAGAC---TTCTCCATTCATATCAAAGCAGTGGGG
AspTrpThrGluAsnLeuIleArgAlaPheGluGlnGlnTyrSerProIle{Pr} >>>
||| ||| ||||||||||||||| ||| ||| { }
GlyTrpSerGluSerLeuIleArgAlaPheLysGlnHisSerSerIleLeu{Se}++
GGCTGGTCAGAAAGTCTCATAAGGGCTTTTAAACAGCATTCATCAATTCTC{AG}gt
> Target Intron 1 >>>> {o}ArgIleGluValAspGlyProPheGlyThrAla
1127 bp { }||||||||||||||||||||| |||||||||
--{r}ArgIleGluValAspGlyProLeuGlyThrAla
gt{C}AGAATTGAAGTGGATGGCCCCTTAGGCACAGCC
SerGluAspVal-PheGlnTyrGluValAlaValLeuValGlyAlaGlyIleGlyValTh
||||||||||||#||||||||| |||||| ||||||||| ||||||||||||||
SerGluAspVal#PheGlnTyrIleValAlaMetLeuValGlyValGlyIleGlyValTh
AGTGAGGATGTTTTTCCAGTATATAGTAGCTATGCTGGTTGGAGTAGGAATTGGGGTCAC
rProPheAlaSerIleLeuLysSerIleTrpTyrLysPheGlnCysAlaAspHisAsnLe
| |||||||||||||||||| |||||||||||||||||| ||| ||| ||
rSerPheAlaSerIleLeuLysCysIleTrpTyrLysPheGlnHisAlaAsnHisLysLe
CTCCTTTGCTTCCATTTTGAAATGCATCTGGTACAAATTTCAGCATGCAAACCACAAGCT
uLysThrLysLys >>>> Target Intron 2 >>>> IleTyrPheTyrTrpIle
||||||| ||| 852 bp ||||||||||||||||||
uLysThrArgLys+- ++IleTyrPheTyrTrpIle
TAAAACAAGAAAAgg agATCTATTTCTACTGGATC
CysArgGluThrGlyAlaPheSerTrpPheAsnAsnLeuLeuThrSerLeuGluGlnGlu
|||||||||||||||||| ||| ||| ||||||||||||||||||
PheArgGluThrGlyAlaPheAlaCysPheSerGluLeuIleThrSerLeuGluGlnGlu
TTCAGGGAGACAGGTGCTTTTGCCTGTTTCAGTGAATTAATTACTTCTCTGGAACAGGAG
MetGluGluLeuGlyLysValGlyPheLeuAsnTyrArgLeuPheLeuThrGlyTrpAsp
|||||||||||||||||| ||||||||| |||||| |||||||||||||||
MetGluGluLeuGlyLysThrSerPheLeuAsnPheArgLeuTyrLeuThrGlyTrpAsp
ATGGAGGAATTAGGCAAAACGAGTTTTCTAAACTTCCGTCTTTACCTCACCGGATGGGAC
SerAsnIle >>>> Target Intron 3 >>>> ValGlyHisAlaAlaLeuAsnP
|||||| 200 bp ||| |||||| |
SerAsnAsn++ ++AlaGlyAsnGluAlaLeuSerP
AGCAACAATgt agGCTGGTAATGAAGCATTGAGCT
heAspLysAlaThrAspIleValThrGlyLeuLysGlnLysThrSerPheGlyArgProM
||||| ||||||||| ||||||||||||||| |||||| ||| |||
heAspAsnProThrAspIleLeuThrGlyLeuLysGlnGlnThrSerSerGlyLysProV
TTGACAATCCCACTGACATCCTGACAGGTTTGAAACAGCAAACCTCCTCAGGGAAACCAG
etTrpAspAsnGluPheSerThrIleAlaThrSerHisPro{Ly} >>>> Target I
||| |||||| ||||||||||||||| |||{ } 5787
alTrpGluAsnGluTyrSerThrIleAlaThrAlaTyrPro{Ar}++
TGTGGGAAAATGAGTATTCTACAATAGCTACTGCCTACCCC{AG}gt
ntron 4 >>>> {s}SerValValGlyValPheLeuCysGlyProArgThrLeuAlaL
bp { }|||||||||||||||||||||||||||||| ||||||||||
+-{g}SerValValGlyValPheLeuCysGlyProTrpThrLeuAlaL
aa{G}TCTGTGGTGGGAGTTTTCTTATGTGGTCCTTGGACTTTGGCAA
ysSerLeuArgLysCysCysHisArgTyrSerSerLeuAspProArgLysValGlnPheT
|||||||| ||||||||| |||||| ||||||||||||||||||||||||||||
ysSerLeuSerLysCysCysTyrArgTyrPheSerLeuAspProArgLysValGlnPheT
AGAGTCTAAGCAAATGCTGTTACCGATACTTCAGTCTGGATCCTAGGAAGGTTCAATTCT
yrPheAsnLysGluAsnPhe
|||||||| |||||||||
yrPheAsnArgGluAsnPhe
ACTTCAACAGGGAAAATTTC
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