Gene information

Basic information

Official Symbol	MCC
Description	mutated in colorectal cancers
Other Aliases	MCC1
Other Description	colorectal mutant cancer protein
Mutation type	premature termination 200:G->TAA, premature termination 473:R->TGA
Location	Scaffold000195_1:1280810 1170399 - ± bp flank
Wiki	Wikipedia GeneCard

Sequence

MCC

AGCGTCTAACCTCGGCTTCTTTCTGTGTGCCCACAGCTCCACTCAGCAGC
CCTGGCGTCCCTCAAGGGAGACATAGTGGAGCTCAGTAAACGTCTGCAGC
AGACAGAGCGGGAGCGAGACCTTCTGGAAAAGAAACTAGCCAAGGCACAG
TGTGAGCAGTCGCACCTCATGAGAGAACACGAGGACGTGCAGGAGCGGAC
GACGCTGCGGTACGAGGAGCGCATCACCGAGCTGCACAGCATCATCGCCG
AGCTCAACAAGAAGATCGACCGCCTGCAGGGCAGCACCATCAGAGAGGAG
GATGAGTGCTCGGAACTGCGGTCCGAGCTCAGCCAGAGTCAGCTGGAGGG
CAACGAGGACTGCCGGAGCCTGGACCAGGACCAGACCTCTGTGTCCGTCC
CTGAGAACCAGTCCACCGTGGTCACTGCAGACGTGGATACCTGCAGTGAC
CTGAACTCGGAGCTGCAGCGGGTGCTGACGGGGCTGGAGCACGTCGTGTG
CTGCAGGAAGAAGAGCAGCTGCAGCCTCTCCGTGGCCGAGGTGGACCGGC
ACATCGAGCAGCTCACCACGGCCAGCGAGCACTGCGACCTGGCTATTAAG
GTAGGCCTCACCGCCTGCTGCCTCCTGACTGCGCGTNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNCGGTGGGAGCAGCAGCTGGCCGGGCTGCGGGAAG
AGAACGAGAGCCTGACCGCCATGCTGTGCAGCAAGGAGGAGGAGCTGCAC
CGGACCAAGGCCACCGTGGGCGCCATCCGCGAGGAGCGTGACCGGCTGCG
CAGGAGGGTGCGGGAGCTGCAGAGGTGACTCCAGAGCATGCAGGCCACAG
GCCCCTCCAGCCCCGGCCGCCTCACCTCTGCCAACCGCCCGATCAACCCC
AGCACGGGGGAGCTGAGCACCAGCAGCAGCAGCAATGACATCCCCATCGC
TAAGATTGCTGAGAGGGTGAAGCTGTCAAAGACAAGGTCGGAATCCTCCT
CGTCTGATCGGCCAGTCCTGGGCTCAGAAATCAGCAGCATCGGGGTGTCC
AGCAGTGTGGCAGAACACCTGGCCCACTCGCTCCAGGACTGCTCCAACAT
CCAGGAGATTTTCCAAACCCTCTACTCCCATGGCTCTGCCATCTCCGAAA
GCAAGATCCGCGAGTTCGAGGTGGAAACGGAGCGGCTGAACAGCCGGATC
GAACACCTCAAGTCCCAGAACGACCTCCTGACCATCACCCTGGAGGAGTG
CAAGAGCAACGCAGAGCGCATGAGCATGCTGGTCGGGAAGTACGAGTCCA
ACGCCACGGCGCTGCGGCTGGCCCTGCAGTACAGCGAGCAGTGCATCGAG
GCCTACGAACTCCTCCTGGCGCTGGCTGACAGCGAGCAGAGCCTCATCCT
GGGGCAGATCCGGGCCGCCGGCGTGGGGTCCTCCCCCGTAGACCAGTCCG
GGGACGAGAACATCACTCAGATGCTCAAGCGCGCTCACGACTGCCGGAAG
ACGGCCGAGAACGCCGCCAGAGCCCTGCTGCTGAAGCTGGACGGCAGCTG
CGGCACCTTCGCTGTGGCCGGCTGCAGCGCGCAGCCCTGGGAGAGCCTGT
CCTCCAACAGCCACACCAGCACCACCAGCTCCACGGCCAGCAGCTGCGAC
ACGGAGTTCACAAAGGAGGACGAGCAGAGGCTGAAGGACTACATCCGGCA
GCTCAGGAACGACAGGGCCGCCGTCAAGCTGACCACGCTGGAGCTGGAGA
GCGTCCACATCGACCCGCTCAGCTGCGACGTCAAGCCGCGGGGGGACAGC
CAGCGGCTGGACCTGGAGAATGCGGTGCTCATGCAGGAGCTGATGGCCAT
GAAGGAGGAGATGGCGGAGCTGAAGGCCCAGCTGTACCTCCTGGAGAAGG
AGAGGAAGGCGCTGGAGCTGAAGCTGAGCACGCGGGAGGCGCAGGAGCAG
GCCTACCTGGTGCACATCGAGCACCTCAAGTCCGAGCTGGAGGAGCAGGA
GCAGCACACGCAGTCACTCGGCCCCGGCGGCAAGGACAGGCCCGGCAAGG
AATGCGCCGACGCCACCCCAGCCCTGTCCCTGGCTGAGCTACGGACCACG
TGCAGCGACAGTGAGCTGGCCGCGGAGTTCGCCAGCGCCATCCGCAGAGA
GAAGAAGCTGAAGGCCAGGGTGCAGGAGCTGGTGGGCGCCCTGGAGAGGC
TCACCAAGAGCAGCGAGGTCCGGCACCAGCAGTCGGCGGAGTTCGTGAAC
GACCTGAAGCGGGCCAAC

Alignment

Align specie	Pep length	Pep align begin	Pep align end	Mutaion type and postion
Human	1019	198	959	Premature termination 200:G->TAA, Premature termination 473:R->TGA

 Instructions:
 *** -> premature termination codon;  # -> frame shift 

 Alignment:
 Human     pep sequence --->
 ||||||||||||||||||||||
 Treeshrew pep sequence --->
 Treeshrew cds sequence --->

SerValGlyGlySerTyrLeuGluLeuAlaAsnThrLeuHisSerAlaAlaLeuAlaS
||||||            |||               ||||||||||||||||||||||
SerVal***ProArgLeuLeuSerValCysProGlnLeuHisSerAlaAlaLeuAlaS
AGCGTCTAACCTCGGCTTCTTTCTGTGTGCCCACAGCTCCACTCAGCAGCCCTGGCGT

erLeuLysGlyAspIleValGluLeuAsnLysArgLeuGlnGlnThrGluArgGluAr
||||||||||||||||||||||||||   |||||||||||||||||||||||||||||
erLeuLysGlyAspIleValGluLeuSerLysArgLeuGlnGlnThrGluArgGluAr
CCCTCAAGGGAGACATAGTGGAGCTCAGTAAACGTCTGCAGCAGACAGAGCGGGAGCG

gAspLeuLeuGluLysLysLeuAlaLysAlaGln  >>>> Target Intron 1 >
||||||||||||||||||||||||||||||||||           14697 bp
gAspLeuLeuGluLysLysLeuAlaLysAlaGln++
AGACCTTCTGGAAAAGAAACTAGCCAAGGCACAGgt

>>>  CysGluGlnSerHisLeuMetArgGluHisGluAspValGlnGluArgThrTh
     |||||||||||||||||||||||||||||||||||||||||||||||||||||
   ++CysGluGlnSerHisLeuMetArgGluHisGluAspValGlnGluArgThrTh
   agTGTGAGCAGTCGCACCTCATGAGAGAACACGAGGACGTGCAGGAGCGGACGAC

rLeuArgTyrGluGluArgIleThrGluLeuHisSerValIleAlaGluLeuAsnLys
|||||||||||||||||||||||||||||||||||||   ||||||||||||||||||
rLeuArgTyrGluGluArgIleThrGluLeuHisSerIleIleAlaGluLeuAsnLys
GCTGCGGTACGAGGAGCGCATCACCGAGCTGCACAGCATCATCGCCGAGCTCAACAAG

LysIleAspArgLeuGlnGlyThrThrIle{Ar}  >>>> Target Intron 2 >
|||||||||||||||||||||   ||||||{||}           12772 bp
LysIleAspArgLeuGlnGlySerThrIle{Ar}++
AAGATCGACCGCCTGCAGGGCAGCACCATC{AG}gt

>>>  {g}GluGluAspGluTyrSerGluLeuArgSerGluLeuSerGlnSerGlnHi
     {|}||||||||||||   |||||||||||||||||||||||||||||||||
   ++{g}GluGluAspGluCysSerGluLeuArgSerGluLeuSerGlnSerGlnLe
   ag{A}GAGGAGGATGAGTGCTCGGAACTGCGGTCCGAGCTCAGCCAGAGTCAGCT

sGluValAsnGluAspSerArgSerMetAspGlnAspGlnThrSerValSerIlePro
 |||   |||||||||   ||||||   ||||||||||||||||||||||||   |||
uGluGlyAsnGluAspCysArgSerLeuAspGlnAspGlnThrSerValSerValPro
GGAGGGCAACGAGGACTGCCGGAGCCTGGACCAGGACCAGACCTCTGTGTCCGTCCCT

GluAsnGlnSerThrMetValThrAlaAspMet{A}  >>>> Target Intron 3
|||||||||||||||   ||||||||||||   {|}           22581 bp
GluAsnGlnSerThrValValThrAlaAspVal{A}++
GAGAACCAGTCCACCGTGGTCACTGCAGACGTG{G}gt

 >>>>  {sp}AsnCysSerAspLeuAsnSerGluLeuGlnArgValLeuThrGlyLe
       {||}   ||||||||||||||||||||||||||||||||||||||||||||
     ++{sp}ThrCysSerAspLeuAsnSerGluLeuGlnArgValLeuThrGlyLe
     ag{AT}ACCTGCAGTGACCTGAACTCGGAGCTGCAGCGGGTGCTGACGGGGCT

uGluAsnValValCysGlyArgLysLysSerSerCysSerLeuSerValAlaGluVal
||||   |||||||||   |||||||||||||||||||||||||||||||||||||||
uGluHisValValCysCysArgLysLysSerSerCysSerLeuSerValAlaGluVal
GGAGCACGTCGTGTGCTGCAGGAAGAAGAGCAGCTGCAGCCTCTCCGTGGCCGAGGTG

AspLysHisIleGluGlnLeuThrThrAlaSerGluHisCysAspLeuAlaIleLys
|||   |||||||||||||||||||||||||||||||||||||||||||||||||||
AspArgHisIleGluGlnLeuThrThrAlaSerGluHisCysAspLeuAlaIleLys+
GACCGGCACATCGAGCAGCTCACCACGGCCAGCGAGCACTGCGACCTGGCTATTAAGg

 >>>> Target Intron 4 >>>>  ThrValGluGluIleGluGlyValLeuGly
          1927 bp                             |||      |||
+                         -+CysCysAlaAspSerArgGlyAspArgGly
t                         cgTGCTGTGCAGACAGTCGAGGAGATCGAGGG

ArgAspLeuTyrProAsnLeuAlaGluGluArgSerArgTrpGluLysGluLeuAlaG
|||                                 |||||||||      |||||||
ArgUnkUnkUnk---UnkUnkUnkUnkUnkUnkUnkArgTrpGluGlnGlnLeuAlaG
CGTNNNNNNNNN---NNNNNNNNNNNNNNNNNNNNNCGGTGGGAGCAGCAGCTGGCCG

lyLeuArgGluGluAsnGluSerLeuThrAlaMetLeuCysSerLysGluGluGluLe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lyLeuArgGluGluAsnGluSerLeuThrAlaMetLeuCysSerLysGluGluGluLe
GGCTGCGGGAAGAGAACGAGAGCCTGACCGCCATGCTGTGCAGCAAGGAGGAGGAGCT

uAsnArgThrLysAlaThrMetAsnAlaIleArgGluGluArgAspArgLeuArgArg
|   |||||||||||||||      |||||||||||||||||||||||||||||||||
uHisArgThrLysAlaThrValGlyAlaIleArgGluGluArgAspArgLeuArgArg
GCACCGGACCAAGGCCACCGTGGGCGCCATCCGCGAGGAGCGTGACCGGCTGCGCAGG

Arg  >>>> Target Intron 5 >>>>  ValArgGluLeuGlnThrArgLeuGl
|||           14841 bp          |||||||||||||||      |||||
Arg++                         ++ValArgGluLeuGlnArg***LeuGl
AGGgt                         agGTGCGGGAGCTGCAGAGGTGACTCCA

nSerValGlnAlaThrGlyProSerSerProGlyArgLeuThrSerThrAsnArgPro
||||   |||||||||||||||||||||||||||||||||||||||   |||||||||
nSerMetGlnAlaThrGlyProSerSerProGlyArgLeuThrSerAlaAsnArgPro
GAGCATGCAGGCCACAGGCCCCTCCAGCCCCGGCCGCCTCACCTCTGCCAACCGCCCG

IleAsnProSerThrGlyGluLeuSerThrSerSerSerSerAsnAspIleProIleA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IleAsnProSerThrGlyGluLeuSerThrSerSerSerSerAsnAspIleProIleA
ATCAACCCCAGCACGGGGGAGCTGAGCACCAGCAGCAGCAGCAATGACATCCCCATCG

laLys  >>>> Target Intron 6 >>>>  IleAlaGluArgValLysLeuSer
|||||           1056 bp           ||||||||||||||||||||||||
laLys++                         ++IleAlaGluArgValLysLeuSer
CTAAGgt                         agATTGCTGAGAGGGTGAAGCTGTCA

LysThrArgSerGluSerSerSerSerAspArgProValLeuGlySerGluIleSerS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LysThrArgSerGluSerSerSerSerAspArgProValLeuGlySerGluIleSerS
AAGACAAGGTCGGAATCCTCCTCGTCTGATCGGCCAGTCCTGGGCTCAGAAATCAGCA

erIleGly  >>>> Target Intron 7 >>>>  ValSerSerSerValAlaGlu
||||||||           2675 bp           |||||||||||||||||||||
erIleGly++                         ++ValSerSerSerValAlaGlu
GCATCGGGgt                         agGTGTCCAGCAGTGTGGCAGAA

HisLeuAlaHisSerLeuGlnAspCysSerAsnIleGlnGluIlePheGlnThrLeuT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HisLeuAlaHisSerLeuGlnAspCysSerAsnIleGlnGluIlePheGlnThrLeuT
CACCTGGCCCACTCGCTCCAGGACTGCTCCAACATCCAGGAGATTTTCCAAACCCTCT

yrSerHisGlySerAlaIleSerGluSerLysIleArgGluPheGluValGluThrGl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yrSerHisGlySerAlaIleSerGluSerLysIleArgGluPheGluValGluThrGl
ACTCCCATGGCTCTGCCATCTCCGAAAGCAAGATCCGCGAGTTCGAGGTGGAAACGGA

uArgLeuAsn{Se}  >>>> Target Intron 8 >>>>  {r}ArgIleGluHis
||||||||||{||}           4394 bp           {|}||||||||||||
uArgLeuAsn{Se}++                         ++{r}ArgIleGluHis
GCGGCTGAAC{AG}gt                         ag{C}CGGATCGAACAC

LeuLysSerGlnAsnAspLeuLeuThrIleThrLeuGluGluCysLysSerAsnAlaG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuLysSerGlnAsnAspLeuLeuThrIleThrLeuGluGluCysLysSerAsnAlaG
CTCAAGTCCCAGAACGACCTCCTGACCATCACCCTGGAGGAGTGCAAGAGCAACGCAG

luArgMetSerMetLeuValGlyLysTyrGluSerAsnAlaThrAlaLeuArgLeuAl
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luArgMetSerMetLeuValGlyLysTyrGluSerAsnAlaThrAlaLeuArgLeuAl
AGCGCATGAGCATGCTGGTCGGGAAGTACGAGTCCAACGCCACGGCGCTGCGGCTGGC

aLeuGlnTyr{Se}  >>>> Target Intron 9 >>>>  {r}GluGlnCysIle
||||||||||{||}           3459 bp           {|}||||||||||||
aLeuGlnTyr{Se}++                         ++{r}GluGlnCysIle
CCTGCAGTAC{AG}gt                         ag{C}GAGCAGTGCATC

GluAlaTyrGluLeuLeuLeuAlaLeuAlaGluSerGluGlnSerLeuIleLeuGlyG
||||||||||||||||||||||||||||||   |||||||||||||||||||||||||
GluAlaTyrGluLeuLeuLeuAlaLeuAlaAspSerGluGlnSerLeuIleLeuGlyG
GAGGCCTACGAACTCCTCCTGGCGCTGGCTGACAGCGAGCAGAGCCTCATCCTGGGGC

lnPheArgAlaAlaGlyValGlySerSerPro{G}  >>>> Target Intron 10
||   |||||||||||||||||||||||||||{ }            2514 bp
lnIleArgAlaAlaGlyValGlySerSerPro{V}++
AGATCCGGGCCGCCGGCGTGGGGTCCTCCCCC{G}gt

 >>>>  {ly}AspGlnSerGlyAspGluAsnIleThrGlnMetLeuLysArgAlaHi
       {  }|||||||||||||||||||||||||||||||||||||||||||||||
     -+{al}AspGlnSerGlyAspGluAsnIleThrGlnMetLeuLysArgAlaHi
     tg{TA}GACCAGTCCGGGGACGAGAACATCACTCAGATGCTCAAGCGCGCTCA

sAspCysArgLysThrAlaGluAsnAlaAlaLysAlaLeuLeuMetLysLeuAspGly
|||||||||||||||||||||||||||||||   |||||||||   ||||||||||||
sAspCysArgLysThrAlaGluAsnAlaAlaArgAlaLeuLeuLeuLysLeuAspGly
CGACTGCCGGAAGACGGCCGAGAACGCCGCCAGAGCCCTGCTGCTGAAGCTGGACGGC

SerCysGlyGlyAlaPheAlaValAlaGlyCysSerValGlnProTrpGluSerLeuS
||||||   |||   |||||||||||||||||||||   |||||||||||||||||||
SerCys---GlyThrPheAlaValAlaGlyCysSerAlaGlnProTrpGluSerLeuS
AGCTGC---GGCACCTTCGCTGTGGCCGGCTGCAGCGCGCAGCCCTGGGAGAGCCTGT

erSerAsnSerHisThr{Se}  >>>> Target Intron 11 >>>>  {r}ThrT
|||||||||||||||||{||}           11582 bp           {|}||||
erSerAsnSerHisThr{Se}++                          ++{r}ThrT
CCTCCAACAGCCACACC{AG}gt                          ag{C}ACCA

hrSerSerThrAlaSerSerCysAspThrGluPheThrLysGluAspGluGlnArgLe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hrSerSerThrAlaSerSerCysAspThrGluPheThrLysGluAspGluGlnArgLe
CCAGCTCCACGGCCAGCAGCTGCGACACGGAGTTCACAAAGGAGGACGAGCAGAGGCT

uLysAspTyrIleGlnGlnLeuLysAsnAspArgAlaAlaValLysLeuThrMetLeu
|||||||||||||   ||||||   |||||||||||||||||||||||||||   |||
uLysAspTyrIleArgGlnLeuArgAsnAspArgAlaAlaValLysLeuThrThrLeu
GAAGGACTACATCCGGCAGCTCAGGAACGACAGGGCCGCCGTCAAGCTGACCACGCTG

GluLeuGluSerIleHisIleAspProLeuSerTyrAspValLysProArgGlyAspS
||||||||||||   ||||||||||||||||||   ||||||||||||||||||||||
GluLeuGluSerValHisIleAspProLeuSerCysAspValLysProArgGlyAspS
GAGCTGGAGAGCGTCCACATCGACCCGCTCAGCTGCGACGTCAAGCCGCGGGGGGACA

erGlnArgLeuAspLeuGluAsnAlaValLeuMetGlnGluLeuMetAlaMetLys
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
erGlnArgLeuAspLeuGluAsnAlaValLeuMetGlnGluLeuMetAlaMetLys++
GCCAGCGGCTGGACCTGGAGAATGCGGTGCTCATGCAGGAGCTGATGGCCATGAAGgt

>>>> Target Intron 12 >>>>  GluGluMetAlaGluLeuLysAlaGlnLeu
          5183 bp           ||||||||||||||||||||||||||||||
                          ++GluGluMetAlaGluLeuLysAlaGlnLeu
                          agGAGGAGATGGCGGAGCTGAAGGCCCAGCTG

TyrLeuLeuGluLysGluLysLysAlaLeuGluLeuLysLeuSerThrArgGluAlaG
||||||||||||||||||   |||||||||||||||||||||||||||||||||||||
TyrLeuLeuGluLysGluArgLysAlaLeuGluLeuLysLeuSerThrArgGluAlaG
TACCTCCTGGAGAAGGAGAGGAAGGCGCTGGAGCTGAAGCTGAGCACGCGGGAGGCGC

lnGluGlnAlaTyrLeuValHisIleGluHisLeuLysSerGluValGluGluGlnLy
||||||||||||||||||||||||||||||||||||||||||||   |||||||||
lnGluGlnAlaTyrLeuValHisIleGluHisLeuLysSerGluLeuGluGluGln--
AGGAGCAGGCCTACCTGGTGCACATCGAGCACCTCAAGTCCGAGCTGGAGGAGCAG--

sGluGlnArgMetArgSerLeuSerSerThrSerSerGlySerLysAspLysProGly
 ||||||         ||||||               |||   ||||||   ||||||
-GluGlnHisThrGlnSerLeu---------GlyProGlyGlyLysAspArgProGly
-GAGCAGCACACGCAGTCACTC---------GGCCCCGGCGGCAAGGACAGGCCCGGC

Lys  >>>> Target Intron 13 >>>>  GluCysAlaAspAlaAlaSerProA
|||            3261 bp           ||||||||||||   |||   ||||
Lys++                          ++GluCysAlaAsp---AlaThrProA
AAGgt                          agGAATGCGCCGAC---GCCACCCCAG

laLeuSerLeuAlaGluLeuArgThrThrCysSerGluAsnGluLeuAlaAlaGluPh
|||||||||||||||||||||||||||||||||||      |||||||||||||||||
laLeuSerLeuAlaGluLeuArgThrThrCysSerAspSerGluLeuAlaAlaGluPh
CCCTGTCCCTGGCTGAGCTACGGACCACGTGCAGCGACAGTGAGCTGGCCGCGGAGTT

eThrAsnAlaIleArg{Ar}  >>>> Target Intron 14 >>>>  {g}GluLy
|      |||||||||{||}            7205 bp           {|}|||||
eAlaSerAlaIleArg{Ar}++                          ++{g}GluLy
CGCCAGCGCCATCCGC{AG}gt                          ag{A}GAGAA

sLysLeuLysAlaArgValGlnGluLeuValSerAlaLeuGluArgLeuThrLysSer
|||||||||||||||||||||||||||||||   ||||||||||||||||||||||||
sLysLeuLysAlaArgValGlnGluLeuValGlyAlaLeuGluArgLeuThrLysSer
GAAGCTGAAGGCCAGGGTGCAGGAGCTGGTGGGCGCCCTGGAGAGGCTCACCAAGAGC

SerGluIleArgHisGlnGlnSerAlaGluPheValAsnAspLeuLysArgAlaAsn
||||||   ||||||||||||||||||||||||||||||||||||||||||||||||
SerGluValArgHisGlnGlnSerAlaGluPheValAsnAspLeuLysArgAlaAsn
AGCGAGGTCCGGCACCAGCAGTCGGCGGAGTTCGTGAACGACCTGAAGCGGGCCAAC