| Basic information |
| Official Symbol | KRT28 |
| Description | keratin 28 |
| Other Aliases | KRT25D |
| Other Description | CK-28; K25D; K28; cytokeratin-28; keratin 25D; keratin, type I cytoskeletal 28; keratin-25D; keratin-28; type I inner root sheath specific keratin 25 irs4; type I inner root sheath-specific keratin-K25irs4 |
| Mutation type | Insert and frame-shift 450-451:T-S^CA |
| Location | Scaffold000477_1:2182229 2172461 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| KRT28 |
ATGTCTCTTCGATTTTCTGGTGGATCCAGGCATATTTGCTTACGGCCTGG AACTGGATCAGCTGGACCATCCAACGGAGGCACACGCTTTGCAGGCAGCA ATGCATGTGGCAGCTCGGTTGCTGGAAGTGGATTTTCCTTGGGAGGAGGC TTGGGCAGTGTACCCGGTGGGAGTCATGCCGGTGGTGCCCTTGGAAATGC TGTCTGTGTTGGCTTTGCTGCGAGTGAAGGGGGACTTCTCTCTGGAAATG AGAAGGTGACCATGCAAAATCTTAATGACCGCTTGGCATCCTACCTGGAT AGCGTGCGAGCTCTGGAGGAGGCAAATACTGAATTAGAGAGAAAAATCAA GGGTTGGTATGAAAAATACGGACCTGGATCTTGCCGAGGACTTGATCATG ACTACAGCCGATACCATCTAACAATCGAGGATCTTAAGAATAAGGTTATC TCTTCCACTACTGCTAATGCTAATGTCATTCTACAGATTGATAATGCCAG ACTGGCCGCTGATGATTTCCGGCTAAAGTATGAAAATGAGCTTACCCTTC ACCAAAATGTAGAGGCAGACATCAATGGATTACGGCGTGTCCTGGATGAG CTGACCCTCTGCAGAACTGACCAAGAACTGCAGTATGAATCCCTGAGTGA AGAGATGACCTATCTCAAGAAGAACCATGATGCGGAGATGAAGGCTCTGC AGTGCGCAGCCGGAGGTAACGTGAATGTGGAGATGAACGCTGCTCCCGGA GTGGACCTCACAGTTCTGCTGAACAACATGCGAGCGGAGTATGAGGCCCT TGCTGAGCAGAACCGCAGGGATGCAGAAGCCTGGTTCAACGAAAAGAGTG CCACTCTGCAGCAGCAGATCTCCGACGACGCTGGTGCAGCCACCACCGCC AGAAACGAGCTGACCGAGATGAGGCGCAGCCTGCAGACCCTGGAGATCCA GCTGCAATCCCTGCTGGCAACGAAACACTCCCTGGAGTGCTCCCTGGCAG AGACCGAGGGCAACTACTGCACGCAGCTGGCCCAGATCCAGGCTCAGATC GGGGCCCTGGAGGAGCAGCTGCACCAGGTCAGAACTGAGACCGAGGGCCA GAAACTTGAGCATGAGCAGCTCCTGGACATCAAAGTCCACCTGGAAAAAG AAATTGAGACGTACTGCCGCCTGCTGGATGGTGATGGAAATTCGTGCTCC AAATCAAAGGTTTTTGGATCAGGAAGTTCAGGGAATCCATCGAAAGATTT ATCCAAAACCACATTGGTAAAGACAGTGGTTGAAGAGATAGATCAACGTG GTAAAGTGCTTTCATCGAGGGTTCACTCCATTGAAGAAAAGTCTAAAGTG ACCAGTGGCAAGGCAGAACAAAGGGCTCCTTTC |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 464 | 1 | 464 | Insert and frame-shift 450-451:T-S^CA |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
MetSerLeuGlnPheSerAsnGlySerArgHisValCysLeuArgSerGlyAlaGlySer
||||||||| |||||| |||||||||||| ||||||||| ||| ||||||
MetSerLeuArgPheSerGlyGlySerArgHisIleCysLeuArgProGlyThrGlySer
ATGTCTCTTCGATTTTCTGGTGGATCCAGGCATATTTGCTTACGGCCTGGAACTGGATCA
ValArgProLeuAsnGlyGlyAlaGlyPheAlaGlySerSerAlaCysGlyGlySerVal
||| ||||||||| |||||||||||| ||||||||| ||||||
AlaGlyProSerAsnGlyGlyThrArgPheAlaGlySerAsnAlaCysGlySerSerVal
GCTGGACCATCCAACGGAGGCACACGCTTTGCAGGCAGCAATGCATGTGGCAGCTCGGTT
AlaGlySerGluPheSerCysAlaLeuGlyGlyGlyLeuGlySerValProGlyGlySer
||||||||| |||||| ||||||||||||||||||||||||||||||||||||
AlaGlySerGlyPheSer------LeuGlyGlyGlyLeuGlySerValProGlyGlySer
GCTGGAAGTGGATTTTCC------TTGGGAGGAGGCTTGGGCAGTGTACCCGGTGGGAGT
HisAlaGlyGlyAlaLeuGlyAsnAlaAlaCysIleGlyPheAlaGlySerGluGlyGly
||||||||||||||||||||||||||| ||| ||||||||| ||||||||||||
HisAlaGlyGlyAlaLeuGlyAsnAlaValCysValGlyPheAlaAlaSerGluGlyGly
CATGCCGGTGGTGCCCTTGGAAATGCTGTCTGTGTTGGCTTTGCTGCGAGTGAAGGGGGA
LeuLeuSerGlyAsnGluLysValThrMetGlnAsnLeuAsnAspArgLeuAlaSerTyr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuLeuSerGlyAsnGluLysValThrMetGlnAsnLeuAsnAspArgLeuAlaSerTyr
CTTCTCTCTGGAAATGAGAAGGTGACCATGCAAAATCTTAATGACCGCTTGGCATCCTAC
LeuAspAsnValArgAlaLeuGluGluAlaAsnAlaGluLeuGluArgLysIleLysGly
|||||| |||||||||||||||||||||||| ||||||||||||||||||||||||
LeuAspSerValArgAlaLeuGluGluAlaAsnThrGluLeuGluArgLysIleLysGly
CTGGATAGCGTGCGAGCTCTGGAGGAGGCAAATACTGAATTAGAGAGAAAAATCAAGGGT
TrpTyrGluLysTyrGlyProGlySerCysArgGlyLeuAspHisAspTyrSerArgTyr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TrpTyrGluLysTyrGlyProGlySerCysArgGlyLeuAspHisAspTyrSerArgTyr
TGGTATGAAAAATACGGACCTGGATCTTGCCGAGGACTTGATCATGACTACAGCCGATAC
HisLeuThrIleGluAspLeuLysAsnLys >>>> Target Intron 1 >>>> I
|||||||||||||||||||||||||||||| 1188 bp
HisLeuThrIleGluAspLeuLysAsnLys++ ++V
CATCTAACAATCGAGGATCTTAAGAATAAGgt agG
leIleSerSerThrThrThrAsnAlaAsnValIleLeuGlnIleAspAsnAlaArgLeuA
||||||||||||||| ||||||||||||||||||||||||||||||||||||||||
alIleSerSerThrThrAlaAsnAlaAsnValIleLeuGlnIleAspAsnAlaArgLeuA
TTATCTCTTCCACTACTGCTAATGCTAATGTCATTCTACAGATTGATAATGCCAGACTGG
laAlaAspAspPheArgLeu{Ly} >>>> Target Intron 2 >>>> {s}TyrG
||||||||||||||||||||{||} 529 bp {|}||||
laAlaAspAspPheArgLeu{Ly}++ ++{s}TyrG
CCGCTGATGATTTCCGGCTA{AA}gt ag{G}TATG
luAsnGluLeuThrLeuHisGlnAsnValGluAlaAspIleAsnGlyLeuArgArgValL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luAsnGluLeuThrLeuHisGlnAsnValGluAlaAspIleAsnGlyLeuArgArgValL
AAAATGAGCTTACCCTTCACCAAAATGTAGAGGCAGACATCAATGGATTACGGCGTGTCC
euAspGluLeuThrLeuCysArgThrAspGlnGluLeuGlnTyrGluSerLeuSerGluG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euAspGluLeuThrLeuCysArgThrAspGlnGluLeuGlnTyrGluSerLeuSerGluG
TGGATGAGCTGACCCTCTGCAGAACTGACCAAGAACTGCAGTATGAATCCCTGAGTGAAG
luMetThrTyrLeuLysLysAsnHisGluGlu >>>> Target Intron 3 >>>>
|||||||||||||||||||||||||| 3520 bp
luMetThrTyrLeuLysLysAsnHisAspAla++ +
AGATGACCTATCTCAAGAAGAACCATGATGCGgt a
GluMetLysAlaLeuGlnCysAlaAlaGlyGlyAsnValAsnValGluMetAsnAlaAl
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
+GluMetLysAlaLeuGlnCysAlaAlaGlyGlyAsnValAsnValGluMetAsnAlaAl
gGAGATGAAGGCTCTGCAGTGCGCAGCCGGAGGTAACGTGAATGTGGAGATGAACGCTGC
aProGlyValAspLeuAlaValLeuLeuAsnAsnMetArgAlaGluTyrGluAlaLeuAl
|||||||||||||||| |||||||||||||||||||||||||||||||||||||||||
aProGlyValAspLeuThrValLeuLeuAsnAsnMetArgAlaGluTyrGluAlaLeuAl
TCCCGGAGTGGACCTCACAGTTCTGCTGAACAACATGCGAGCGGAGTATGAGGCCCTTGC
aGluGlnAsnArgLysAspAlaGluAlaTrpPheAsnGluLys >>>> Target Int
||||||||||||| ||||||||||||||||||||||||||| 87 bp
aGluGlnAsnArgArgAspAlaGluAlaTrpPheAsnGluLys++
TGAGCAGAACCGCAGGGATGCAGAAGCCTGGTTCAACGAAAAGgt
ron 4 >>>> SerAlaSerLeuGlnGlnGlnIleSerHisAspSerGlyAlaAlaThr
|||||| |||||||||||||||||| ||| ||||||||||||
++SerAlaThrLeuGlnGlnGlnIleSerAspAspAlaGlyAlaAlaThr
agAGTGCCACTCTGCAGCAGCAGATCTCCGACGACGCTGGTGCAGCCACC
PheAlaArgSerGlnLeuThrGluMetArgArgThrLeuGlnThrLeuGluIleGlnLeu
|||||| |||||||||||||||||| ||||||||||||||||||||||||
ThrAlaArgAsnGluLeuThrGluMetArgArgSerLeuGlnThrLeuGluIleGlnLeu
ACCGCCAGAAACGAGCTGACCGAGATGAGGCGCAGCCTGCAGACCCTGGAGATCCAGCTG
GlnSerLeuMetAlaThr >>>> Target Intron 5 >>>> LysHisSerLeuG
||||||||| |||||| 1929 bp |||||||||||||
GlnSerLeuLeuAlaThr++ ++LysHisSerLeuG
CAATCCCTGCTGGCAACGgt agAAACACTCCCTGG
luCysSerLeuThrGluThrGluSerAsnTyrCysThrGlnLeuAlaGlnIleGlnAlaG
||||||||||| ||||||||| ||||||||||||||||||||||||||||||||||
luCysSerLeuAlaGluThrGluGlyAsnTyrCysThrGlnLeuAlaGlnIleGlnAlaG
AGTGCTCCCTGGCAGAGACCGAGGGCAACTACTGCACGCAGCTGGCCCAGATCCAGGCTC
lnIleGlyAlaLeuGluGluGlnLeuHisGlnValArgThrGluThrGluGlyGlnLysL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lnIleGlyAlaLeuGluGluGlnLeuHisGlnValArgThrGluThrGluGlyGlnLysL
AGATCGGGGCCCTGGAGGAGCAGCTGCACCAGGTCAGAACTGAGACCGAGGGCCAGAAAC
euGluTyrGluHisLeuLeuAspValLysValHisLeuGluLysGluIleGluThrTyrC
||||| ||| ||||||||| ||||||||||||||||||||||||||||||||||
euGluHisGluGlnLeuLeuAspIleLysValHisLeuGluLysGluIleGluThrTyrC
TTGAGCATGAGCAGCTCCTGGACATCAAAGTCCACCTGGAAAAAGAAATTGAGACGTACT
ysArgLeuIleAspGlyAspGly{As} >>>> Target Intron 6 >>>> {n}S
|||||||| ||||||||||||{||} 599 bp {|}|
ysArgLeuLeuAspGlyAspGly{As}++ ++{n}S
GCCGCCTGCTGGATGGTGATGGA{AA}gt ag{T}T
erCysSerLysSerLysGlyPheGlySerGlySerProGlyAsnSerSerLys{A} >>
||||||||||||||||| ||||||||||||||| |||||| ||||||{|}
erCysSerLysSerLysValPheGlySerGlySerSerGlyAsnProSerLys{A}++
CGTGCTCCAAATCAAAGGTTTTTGGATCAGGAAGTTCAGGGAATCCATCGAAA{G}gt
>> Target Intron 7 >>>> {sp}LeuSerLysThrThrLeuValLysThrValV
532 bp {||}|||||||||||||||||||||||||||||||
++{sp}LeuSerLysThrThrLeuValLysThrValV
ag{AT}TTATCCAAAACCACATTGGTAAAGACAGTGG
alGluGluLeuAspGlnArgGlyLysValLeuSerSerArgIleHisSerIleGluGluL
|||||||| |||||||||||||||||||||||||||||| ||||||||||||||||
alGluGluIleAspGlnArgGlyLysValLeuSerSerArgValHisSerIleGluGluL
TTGAAGAGATAGATCAACGTGGTAAAGTGCTTTCATCGAGGGTTCACTCCATTGAAGAAA
ysThr--SerLysMetThrAsnGlyLysThrGluGlnArgValProPhe
|| ##|||||| ||| |||||| ||||||||| ||||||
ys---##SerLysValThrSerGlyLysAlaGluGlnArgAlaProPhe
AG---CATCTAAAGTGACCAGTGGCAAGGCAGAACAAAGGGCTCCTTTC
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