| Basic information |
| Official Symbol | DROSHA |
| Description | drosha, ribonuclease type III |
| Other Aliases | ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN |
| Other Description | RNase III; drosha, double-stranded RNA-specific endoribonuclease; nuclear RNase III Drosha; p241; protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; ribonuclease 3; ribonuclease III, nuclear; ribonuclease type III, nuclear |
| Mutation type | Insert and frame-shift 348-349:L-E^CCAC |
| Location | Scaffold000237_1:2058193 1914231 - |
| Wiki | Wikipedia GeneCard |
| Sequence |
| DROSHA |
CATAGAATGTCGTTCCACCCAGGACGAGGCTGTCCCCGAGGACGAGGAGG ACATGGAGCCAGACCCTCAGCCCCAGCCTTCAGGCCCCAAAATCTGAGAC TTCTTCATCCTCAGCAGCCTCCTGTGCAATATCAATACGAGCCTCCAAGT GCCCCTTCCACCACGTTCTCGAACTCTCCAGCCCCCAATTTTCTGCCTCC ACGACCAGACTTTGTCCCTTTCCCTCCACCCATGCCTCCATCAGCACAAG GCCCTCTTCCCCCCTGCCCAATCCGGCCCCCTTTCCCCAACCACCAGATG AGGCACCCCTTTCCGGTGCCTCCCTGTTTTCCTCCCATGCCACCTCCAAT GCCCTGTCCCAACAACCCCCCAGTCCCTGGAACGCCTCCTGGACAAGGCA GTTTCCCCTTCATGATGCCCCCTCCCTCTGTGCCCCATCCTCCACCCCCT CCAGTCATGCCACAGCAGGTTAATTATCAGTACCCTCCGGGATACTCACA CCACAATTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAGCCCCAGTT CTTTCCCACCCAGTGCTAGTAACAGCAGTAGCCCTCACTTTAGGCACCTT GCTCCTTACCCGCTCCCAAAGGCTACCAGTGAGAGAAGGTCTCCAGAAAG GCTCAAACATTATGACGATCACAGGCACCGAGATCACAGTCATGGGCGAG GCGAGAAGCGCCGGTCCTTGGATCGGCGGGAGCGAGGTCGCAGTCCCAAC AGGAGAAGGCAAGACAGTCGCTACAGATCCGATTACGAACGTGGGAGAAC GCCCTCTCGCCACCGCAGCTATGAGCGGAGCAGAGAGCGGGAACGGGAGA GACACAGGCATCGAGACAACCGAAGATCACCCTCTCTGGAAAGGTCCTAC AAAAAAGAGTATAAGAGATCTGGAAGGAGTAATGGTTTACCAGCTATTCC TGAACCTGCTGGATGCACATCAGAATTACCTGGGGAGATTATTAAAAATA CAGATTCTTGCCCCTCCCCCCCTGCCGAGATTGTGAATCATCGCTCCCCA AGTAGGGAGAAGAAGCGAGCTCGTTGGGAGGAAGAAAAAGACAGGTGGAG TGACAACCAGAGCTCCGGCAAAGAGAAAAACTATACCTCCATCAAGGAAA AGGAGCCGGAGGAGACGCTGACTGACAAAAATGAGGAGGAGGAAGAAGAA CTACTGAAGCCCGTGTGGATCCGATGTACCCATTCAGAAAACTACTATTC CAGTGACCCCATGGATCAGGTGGGAGATTCTACTGTAGTTGGAACAAGTA GACTTCGTGACTTGTATGACAAATTTGAAGAAGAGTTAGGGAGCAGGCAA GAGAAGGCTAAGGCCGCTAGACCTCCGTGGGAACCTCCGAAAACGAAGCT GGACGAGGATTTAGAGAGTTCCAGTGAGTCCGAATGTGAGTCCGATGAAG ACAGCACCTGTTCTAGCAGCTCAGATTCTGAAGTTTTTGACGTTATTGCA GAAATCAAACGCAAAAAGGCTCATCCTGACCGACTTCACGATGAACTTTG GTACAATGACCCAGGCCAGATGAATGACGGGCCACTCTGCAAATGCAGCG CAAAAGCGAGACGCACAGGAATTAGGCACAGCATTTATCCCGGAGAAGAG AACATCAAGCCTTGTCGTCCGATGACCAACAATGCTGGCAGACTTTTCCA CTATCGGATTACGGTTTCCCCCCCTACAAACTTTTTAACTGACAGGCCAA CCGTTATAGAATATGATGATCATGAGTATATCTTCGAAGGATTTTCTATG TTTGCACATGCCCCCCTGACCAATATTCCATTGTGTAAAGTTATTAGATT CAACATAGACTACACAATTCATTTCATTGAAGAGATGATGCCTGAGAATT TTTGTGTAAAAGGGCTTGAACTCTTTTCATTGTTCCTATTCAGAGATATT TTGGAATTATACGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGTCC TCCTTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTC CAGATGGAGGAAAGGAAGTTCTGTCCATGCACCAGATCCTCCTCTACTTA CTCCGGTGTAGCAAAGCACTGGTCCCTGAGGAGGAGATTGCCAATATGCT GCAGTGGGAAGAACTTGAGTGGCAGAAATATGCCGAGGAATGCAAAGGCA TGATCGTGACCAACCCTGGGACGAAACCAAGTTCTGTCCGCATTGATCAA CTGGATCGTGAACAGTTCAACCCTGATGTGATTACTTTCCCAATTATTGT CCACTTTGGGATACGCCCTGCACAGTTGAGTTATGCAGGAGACCCACAGT ATCAGAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAAT AGTCCCAAAGTCAAACAAACTGACAAGCAAAAGCTGGCACAGAGGGAGGA AGCACTCCAAAAAATACGACAGAAGAATACAATGAGGCGGGAGGTAACCG TGGAGCTAAGTAGCCAGGGATTCTGGAAAACCGGCATCCGTTCTGATGTC TGCCAGCATGCCATGATGCTGCCTGTTTTGACCCATCATATCCGCTACCA CCAATGCCTAATGCATCTGGACAAGCTGATAGGATATACTTTCCAAGATC GTTGTCTGTTACAGTTGGCCATGACTCATCCAAGCCATCATTTAAATTTT GGAATGAATCCTGATCACGCCAGGAATTCTTTATCTAACTGTGGAATTCG GCAGCCCAAATACGGAGACAGAAAAGTTCATCACATGCACATGCGTAAGA AAGGAATTAACACCTTAATAAATATTATGTCACGCCTTGGACAAGATGAC CCAACTCCTTCAAGGATTAATCACAATGAAAGACTGGAGTTCCTGGGTGA TGCTGTGGTTGAATTTCTGACCAGTGTCCATTTGTACTATTTGTTTCCTA GTCTGGAAGAAGGAGGATTAGCAACCTACCGGACTGCCATTGTTCAGAAT CAGCACCTTGCCATGCTAGCAAAGAAACTTGAACTGGATCGATTTATGCT ATACGCTCATGGGCCTGACCTTTGTAGAGAATCGGACCTTCGACATGCAA TGGCTAATTGTTTTGAAGCATTAATAGGAGCTGTTTACTTGGAGGGAAGC CTGGAGGAAGCCAAGCAGCTATTTGGACGCTTACTCTTTAATGATCCGGA CCTGCGCGAAGTCTGGCTCAATTATCCTCTCCACCCACTCCAACTACAAG AACCAAATACTGATCGACAACTTATTGAGACTTCTCCAGTTCTGCAGAAA CTTACTGAGTTCGAAGAAGCAATTGGAGTGATTTTTACTCATGTTCGACT TCTGGCAAGGGCATTCACTTTGAGGACTGTGGGATTTAACCATCTGACCT TAGGCCACAACCAGAGGATGGAATTCCTAGGTGACTCCATAATGCAGCTG GTAGCCACAGAGTACTTATTTATTCATTTCCCAGATCATCATGAAGGACA CTTAACTTTGTTGCGAAGCTCTTTGGTGAATAACAGGACTCAAGCCAAGG TAGCAGAGGAGCTGGGCATGCAGGAATATGCCATAACGAACGACAAGACC AAGAGACCCGTGGCCCTTCGGACCAAGACCTTGGCGGACCTCTTGGAATC GTTTATTGCAGCATTGTACATTGATAAGGATTTGGAATATGTTCATACTT TCATGAATGTCTGCTTCTTTCCACGATTAAAAGAGTTCATTTTGAATCAG GATTGGAATGACCCCAAATCCCAGCTGCAGCAGTGTTGCCTGACACTGAG GACAGAAGGCAAAGAGCCAGATATTCCTCTGTACAAGACTCTGCAGACCG TGGGCCCGTCCCATGCTAGAACTTACACTGTGGCTGTGTATTTCAAGGGA GAAAGAATAGGCTGTGGGAAAGGACCAAGCATTCAGCAAGCAGAAATGGG AGCTGCAATGGATGCACTTGAAAAATATAACTTTCCCCAGATGGCCCATC AGAAGCGGTTCATTGAACGGAAATACAGACAGGAGTTGAAGGAGATGAGG TGGGAAAGAGAGCATCAAGAGAGAGAGCCTGATGAGACCGAGGACATGAA GAAG |
| Alignment |
| Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
| Human | 1374 | 8 | 1374 | Insert and frame-shift 348-349:L-E^CCAC |
Instructions:
*** -> premature termination codon; # -> frame shift
Alignment:
Human pep sequence --->
||||||||||||||||||||||
Treeshrew pep sequence --->
Treeshrew cds sequence --->
HisArgMetSerPheHisProGlyArgGlyCysProArgGlyArgGlyGlyHisGlyA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HisArgMetSerPheHisProGlyArgGlyCysProArgGlyArgGlyGlyHisGlyA
CATAGAATGTCGTTCCACCCAGGACGAGGCTGTCCCCGAGGACGAGGAGGACATGGAG
laArgProSerAlaProSerPheArgProGlnAsnLeuArgLeuLeuHisProGlnGl
||||||||||||||||| ||||||||||||||||||||||||||||||||||||||
laArgProSerAlaProAlaPheArgProGlnAsnLeuArgLeuLeuHisProGlnGl
CCAGACCCTCAGCCCCAGCCTTCAGGCCCCAAAATCTGAGACTTCTTCATCCTCAGCA
nProProValGlnTyrGlnTyrGluProProSerAlaProSerThrThrPheSerAsn
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nProProValGlnTyrGlnTyrGluProProSerAlaProSerThrThrPheSerAsn
GCCTCCTGTGCAATATCAATACGAGCCTCCAAGTGCCCCTTCCACCACGTTCTCGAAC
SerProAlaProAsnPheLeuProProArgProAspPheValProPheProProProM
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SerProAlaProAsnPheLeuProProArgProAspPheValProPheProProProM
TCTCCAGCCCCCAATTTTCTGCCTCCACGACCAGACTTTGTCCCTTTCCCTCCACCCA
etProProSerAlaGlnGlyProLeuProProCysProIleArgProProPheProAs
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
etProProSerAlaGlnGlyProLeuProProCysProIleArgProProPheProAs
TGCCTCCATCAGCACAAGGCCCTCTTCCCCCCTGCCCAATCCGGCCCCCTTTCCCCAA
nHisGlnMetArgHisProPheProValProProCysPheProProMetProProPro
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nHisGlnMetArgHisProPheProValProProCysPheProProMetProProPro
CCACCAGATGAGGCACCCCTTTCCGGTGCCTCCCTGTTTTCCTCCCATGCCACCTCCA
MetProCysProAsnAsnProProValProGlyAlaProProGlyGlnGlyThrPheP
||||||||||||||||||||||||||||||||| ||||||||||||||| ||||
MetProCysProAsnAsnProProValProGlyThrProProGlyGlnGlySerPheP
ATGCCCTGTCCCAACAACCCCCCAGTCCCTGGAACGCCTCCTGGACAAGGCAGTTTCC
roPheMetMetProProProSerMetProHisProProProProProValMetProGl
||||||||||||||||||||||| ||||||||||||||||||||||||||||||||
roPheMetMetProProProSerValProHisProProProProProValMetProGl
CCTTCATGATGCCCCCTCCCTCTGTGCCCCATCCTCCACCCCCTCCAGTCATGCCACA
nGlnValAsnTyrGlnTyrProProGlyTyrSerHisHisAsnPheProProProSer
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nGlnValAsnTyrGlnTyrProProGlyTyrSerHisHisAsnPheProProProSer
GCAGGTTAATTATCAGTACCCTCCGGGATACTCACACCACAATTTCCCACCTCCCAGT
PheAsnSerPheGlnAsnAsnProSerSerPheLeuProSerAlaAsnAsnSerSerS
|||||||||||||||||| |||||||||||| ||||||||| ||||||||||
PheAsnSerPheGlnAsnSerProSerSerPheProProSerAlaSerAsnSerSerS
TTTAATAGTTTCCAGAACAGCCCCAGTTCTTTCCCACCCAGTGCTAGTAACAGCAGTA
erProHisPheArgHisLeuProProTyrProLeuProLysAlaProSerGluArgAr
|||||||||||||||||||| ||||||||||||||||||||| |||||||||||
erProHisPheArgHisLeuAlaProTyrProLeuProLysAlaThrSerGluArgAr
GCCCTCACTTTAGGCACCTTGCTCCTTACCCGCTCCCAAAGGCTACCAGTGAGAGAAG
gSerProGluArgLeuLysHisTyrAspAspHisArgHisArgAspHisSerHisGly
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gSerProGluArgLeuLysHisTyrAspAspHisArgHisArgAspHisSerHisGly
GTCTCCAGAAAGGCTCAAACATTATGACGATCACAGGCACCGAGATCACAGTCATGGG
ArgGlyGluArgHisArgSerLeuAspArgArgGluArgGlyArgSerProAspArgA
||||||||| |||||||||||||||||||||||||||||||||||| ||||
ArgGlyGluLysArgArgSerLeuAspArgArgGluArgGlyArgSerProAsnArgA
CGAGGCGAGAAGCGCCGGTCCTTGGATCGGCGGGAGCGAGGTCGCAGTCCCAACAGGA
rgArgGlnAspSerArgTyrArgSerAspTyrAspArgGlyArgThrProSerArgHi
|||||||||||||||||||||||||||||||| |||||||||||||||||||||||
rgArgGlnAspSerArgTyrArgSerAspTyrGluArgGlyArgThrProSerArgHi
GAAGGCAAGACAGTCGCTACAGATCCGATTACGAACGTGGGAGAACGCCCTCTCGCCA
sArgSerTyrGluArgSer{Ar} >>>> Target Intron 1 >>>> {g}Glu
|||||||||||||||||||{||} 4819 bp {|}|||
sArgSerTyrGluArgSer{Ar}++ ++{g}Glu
CCGCAGCTATGAGCGGAGC{AG}gt ag{A}GAG
ArgGluArgGluArgHisArgHisArgAspAsnArgArgSerProSerLeuGluArgS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ArgGluArgGluArgHisArgHisArgAspAsnArgArgSerProSerLeuGluArgS
CGGGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCCTCTCTGGAAAGGT
erTyrLysLysGluTyrLysArgSerGly{Ar} >>>> Target Intron 2 >>
|||||||||||||||||||||||||||||{||} 7526 bp
erTyrLysLysGluTyrLysArgSerGly{Ar}++
CCTACAAAAAAGAGTATAAGAGATCTGGA{AG}gt
>> {g}SerTyrGlyLeuSerValValProGluProAlaGlyCysThrProGluLeu
{|}||| |||||| ||||||||||||||||||||| ||||||
++{g}SerAsnGlyLeuProAlaIleProGluProAlaGlyCysThrSerGluLeu
ag{G}AGTAATGGTTTACCAGCTATTCCTGAACCTGCTGGATGCACATCAGAATTA
ProGlyGluIleIleLysAsnThrAspSerTrp<->AlaProProLeu----GluIle
|||||||||||||||||||||||||||||| |||||| ####||||||
ProGlyGluIleIleLysAsnThrAspSerCysProSerProProAla####GluIle
CCTGGGGAGATTATTAAAAATACAGATTCTTGCCCCTCCCCCCCTGCCCCACGAGATT
ValAsn{Hi} >>>> Target Intron 3 >>>> {s}ArgSerProSerArgG
||||||{||} 232 bp {|}||||||||||||||||
ValAsn{Hi}++ ++{s}ArgSerProSerArgG
GTGAAT{CA}gt ag{T}CGCTCCCCAAGTAGGG
luLysLysArgAlaArgTrpGluGluGluLysAspArgTrpSerAspAsnGlnSerSe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
luLysLysArgAlaArgTrpGluGluGluLysAspArgTrpSerAspAsnGlnSerSe
AGAAGAAGCGAGCTCGTTGGGAGGAAGAAAAAGACAGGTGGAGTGACAACCAGAGCTC
rGlyLysAspLysAsnTyrThrSerIleLysGluLysGluProGluGluThrMetPro
||||||| ||||||||||||||||||||||||||||||||||||||||||
rGlyLysGluLysAsnTyrThrSerIleLysGluLysGluProGluGluThrLeuThr
CGGCAAAGAGAAAAACTATACCTCCATCAAGGAAAAGGAGCCGGAGGAGACGCTGACT
AspLysAsnGluGluGluGluGluGluLeuLeuLysProValTrpIleArgCysThrH
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AspLysAsnGluGluGluGluGluGluLeuLeuLysProValTrpIleArgCysThrH
GACAAAAATGAGGAGGAGGAAGAAGAACTACTGAAGCCCGTGTGGATCCGATGTACCC
isSerGluAsnTyrTyrSerSerAspProMetAspGlnVal >>>> Target Int
||||||||||||||||||||||||||||||||||||||||| 3626 b
isSerGluAsnTyrTyrSerSerAspProMetAspGlnVal++
ATTCAGAAAACTACTATTCCAGTGACCCCATGGATCAGGTGgt
ron 4 >>>> GlyAspSerThrValValGlyThrSerArgLeuArgAspLeuTyrA
p ||||||||||||||||||||||||||||||||||||||||||||||
++GlyAspSerThrValValGlyThrSerArgLeuArgAspLeuTyrA
agGGAGATTCTACTGTAGTTGGAACAAGTAGACTTCGTGACTTGTATG
spLysPheGluGluGluLeuGlySerArgGlnGluLysAlaLysAlaAlaArgProPr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
spLysPheGluGluGluLeuGlySerArgGlnGluLysAlaLysAlaAlaArgProPr
ACAAATTTGAAGAAGAGTTAGGGAGCAGGCAAGAGAAGGCTAAGGCCGCTAGACCTCC
oTrpGluProProLysThrLysLeuAspGluAspLeu{G} >>>> Target Intr
|||||||||||||||||||||||||||||||||||||{|} 3421 bp
oTrpGluProProLysThrLysLeuAspGluAspLeu{G}++
GTGGGAACCTCCGAAAACGAAGCTGGACGAGGATTTA{G}gt
on 5 >>>> {lu}SerSerSerGluSerGluCysGluSerAspGluAspSerThrC
{||}|||||||||||||||||||||||||||||||||||||||||||
++{lu}SerSerSerGluSerGluCysGluSerAspGluAspSerThrC
ag{AG}AGTTCCAGTGAGTCCGAATGTGAGTCCGATGAAGACAGCACCT
ysSerSerSerSerAspSerGluValPheAspValIleAlaGluIleLysArgLysLy
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ysSerSerSerSerAspSerGluValPheAspValIleAlaGluIleLysArgLysLy
GTTCTAGCAGCTCAGATTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAA
sAlaHisProAspArgLeuHisAspGluLeuTrpTyrAsnAspProGlyGln >>>>
||||||||||||||||||||||||||||||||||||||||||||||||||||
sAlaHisProAspArgLeuHisAspGluLeuTrpTyrAsnAspProGlyGln++
GGCTCATCCTGACCGACTTCACGATGAACTTTGGTACAATGACCCAGGCCAGgt
Target Intron 6 >>>> MetAsnAspGlyProLeuCysLysCysSerAlaLy
3474 bp |||||||||||||||||||||||||||||||||||
++MetAsnAspGlyProLeuCysLysCysSerAlaLy
agATGAATGACGGGCCACTCTGCAAATGCAGCGCAAA
sAlaArgArgThrGlyIleArgHisSerIleTyrProGlyGluGlu >>>> Targe
|||||||||||||||||||||||||||||||||||||||||||||| 6
sAlaArgArgThrGlyIleArgHisSerIleTyrProGlyGluGlu++
AGCGAGACGCACAGGAATTAGGCACAGCATTTATCCCGGAGAAGAGgt
t Intron 7 >>>> AlaIleLysProCysArgProMetThrAsnAsnAlaGlyAr
773 bp ||||||||||||||||||||||||||||||||||||||
++AsnIleLysProCysArgProMetThrAsnAsnAlaGlyAr
agAACATCAAGCCTTGTCGTCCGATGACCAACAATGCTGGCAG
gLeuPheHisTyrArgIleThrValSerProProThrAsnPheLeu >>>> Targe
|||||||||||||||||||||||||||||||||||||||||||||| 3
gLeuPheHisTyrArgIleThrValSerProProThrAsnPheLeu++
ACTTTTCCACTATCGGATTACGGTTTCCCCCCCTACAAACTTTTTAgt
t Intron 8 >>>> ThrAspArgProThrValIleGluTyrAspAspHisGluTy
619 bp |||||||||||||||||||||||||||||||||||||||||
++ThrAspArgProThrValIleGluTyrAspAspHisGluTy
agACTGACAGGCCAACCGTTATAGAATATGATGATCATGAGTA
rIlePheGluGlyPheSerMetPheAlaHisAlaProLeuThrAsn >>>> Targe
|||||||||||||||||||||||||||||||||||||||||||||| 6
rIlePheGluGlyPheSerMetPheAlaHisAlaProLeuThrAsn++
TATCTTCGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATgt
t Intron 9 >>>> IleProLeuCysLysValIleArgPheAsnIleAspTyrTh
545 bp |||||||||||||||||||||||||||||||||||||||||
++IleProLeuCysLysValIleArgPheAsnIleAspTyrTh
agATTCCATTGTGTAAAGTTATTAGATTCAACATAGACTACAC
rIleHisPheIleGluGluMetMetProGlu >>>> Target Intron 10 >>>
||||||||||||||||||||||||||||||| 1529 bp
rIleHisPheIleGluGluMetMetProGlu++
AATTCATTTCATTGAAGAGATGATGCCTGAGgt
> AsnPheCysValLysGlyLeuGluLeuPheSerLeuPheLeuPheArgAspIleL
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
++AsnPheCysValLysGlyLeuGluLeuPheSerLeuPheLeuPheArgAspIleL
agAATTTTTGTGTAAAAGGGCTTGAACTCTTTTCATTGTTCCTATTCAGAGATATTT
euGluLeuTyrAspTrpAsnLeuLys{G} >>>> Target Intron 11 >>>>
||||||||||||||||||||||||||{|} 1346 bp
euGluLeuTyrAspTrpAsnLeuLys{G}++ +
TGGAATTATACGACTGGAATCTTAAA{G}gt a
{ly}ProLeuPheGluAspSerProProCysCysProArgPheHisPheMetProAr
{||}|||||||||||||||||||||||||||||||||||||||||||||||||||||
+{ly}ProLeuPheGluAspSerProProCysCysProArgPheHisPheMetProAr
g{GT}CCTTTGTTTGAAGACAGTCCTCCTTGCTGCCCAAGATTTCATTTCATGCCACG
gPheValArgPheLeuPro{A} >>>> Target Intron 12 >>>> {sp}Gl
|||||||||||||||||||{|} 15924 bp {||}||
gPheValArgPheLeuPro{A}++ ++{sp}Gl
TTTTGTAAGATTTCTTCCA{G}gt ag{AT}GG
yGlyLysGluValLeuSerMetHisGlnIleLeuLeuTyrLeuLeuArgCysSerLys
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yGlyLysGluValLeuSerMetHisGlnIleLeuLeuTyrLeuLeuArgCysSerLys
AGGAAAGGAAGTTCTGTCCATGCACCAGATCCTCCTCTACTTACTCCGGTGTAGCAAA
AlaLeuValProGluGluGluIleAlaAsnMetLeuGlnTrpGluGluLeuGluTrpG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AlaLeuValProGluGluGluIleAlaAsnMetLeuGlnTrpGluGluLeuGluTrpG
GCACTGGTCCCTGAGGAGGAGATTGCCAATATGCTGCAGTGGGAAGAACTTGAGTGGC
lnLysTyrAlaGluGluCysLysGlyMetIleValThrAsnProGlyThr >>>> T
||||||||||||||||||||||||||||||||||||||||||||||||||
lnLysTyrAlaGluGluCysLysGlyMetIleValThrAsnProGlyThr++
AGAAATATGCCGAGGAATGCAAAGGCATGATCGTGACCAACCCTGGGACGgt
arget Intron 13 >>>> LysProSerSerValArgIleAspGlnLeuAspArg
4592 bp ||||||||||||||||||||||||||||||||||||
++LysProSerSerValArgIleAspGlnLeuAspArg
agAAACCAAGTTCTGTCCGCATTGATCAACTGGATCGT
GluGlnPheAsnProAspValIleThrPheProIleIleValHisPheGlyIleArgP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GluGlnPheAsnProAspValIleThrPheProIleIleValHisPheGlyIleArgP
GAACAGTTCAACCCTGATGTGATTACTTTCCCAATTATTGTCCACTTTGGGATACGCC
roAlaGlnLeuSerTyrAlaGlyAspPro{Gl} >>>> Target Intron 14 >
|||||||||||||||||||||||||||||{||} 1701 bp
roAlaGlnLeuSerTyrAlaGlyAspPro{Gl}++
CTGCACAGTTGAGTTATGCAGGAGACCCA{CA}gt
>>> {n}TyrGlnLysLeuTrpLysSerTyrValLysLeuArgHisLeuLeuAlaAs
{|}||||||||||||||||||||||||||||||||||||||||||||||||||
++{n}TyrGlnLysLeuTrpLysSerTyrValLysLeuArgHisLeuLeuAlaAs
ag{G}TATCAGAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAA
nSerProLysValLysGlnThrAspLysGlnLysLeuAlaGlnArgGlu >>>> Ta
|||||||||||||||||||||||||||||||||||||||||||||||||
nSerProLysValLysGlnThrAspLysGlnLysLeuAlaGlnArgGlu++
TAGTCCCAAAGTCAAACAAACTGACAAGCAAAAGCTGGCACAGAGGGAGgt
rget Intron 15 >>>> GluAlaLeuGlnLysIleArgGlnLysAsnThrMetA
1372 bp |||||||||||||||||||||||||||||||||||||
++GluAlaLeuGlnLysIleArgGlnLysAsnThrMetA
agGAAGCACTCCAAAAAATACGACAGAAGAATACAATGA
rgArgGluValThrValGluLeuSerSerGlnGlyPheTrpLysThrGlyIleArgSe
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rgArgGluValThrValGluLeuSerSerGlnGlyPheTrpLysThrGlyIleArgSe
GGCGGGAGGTAACCGTGGAGCTAAGTAGCCAGGGATTCTGGAAAACCGGCATCCGTTC
rAspValCysGln >>>> Target Intron 16 >>>> HisAlaMetMetLeu
||||||||||||| 8804 bp |||||||||||||||
rAspValCysGln++ ++HisAlaMetMetLeu
TGATGTCTGCCAGgt agCATGCCATGATGCTG
ProValLeuThrHisHisIleArgTyrHisGlnCysLeuMetHisLeuAspLysLeuI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ProValLeuThrHisHisIleArgTyrHisGlnCysLeuMetHisLeuAspLysLeuI
CCTGTTTTGACCCATCATATCCGCTACCACCAATGCCTAATGCATCTGGACAAGCTGA
leGlyTyrThrPheGlnAspArgCysLeuLeuGln >>>> Target Intron 17
||||||||||||||||||||||||||||||||||| 517 bp
leGlyTyrThrPheGlnAspArgCysLeuLeuGln++
TAGGATATACTTTCCAAGATCGTTGTCTGTTACAGgt
>>>> LeuAlaMetThrHisProSerHisHisLeuAsnPheGlyMetAsnProAsp
|||||||||||||||||||||||||||||||||||||||||||||||||||
++LeuAlaMetThrHisProSerHisHisLeuAsnPheGlyMetAsnProAsp
agTTGGCCATGACTCATCCAAGCCATCATTTAAATTTTGGAATGAATCCTGAT
HisAlaArgAsnSerLeuSerAsnCysGlyIleArgGlnProLysTyrGlyAspArgL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HisAlaArgAsnSerLeuSerAsnCysGlyIleArgGlnProLysTyrGlyAspArgL
CACGCCAGGAATTCTTTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAA
ysValHisHisMetHisMetArgLysLys{G} >>>> Target Intron 18 >>
|||||||||||||||||||||||||||||{|} 1416 bp
ysValHisHisMetHisMetArgLysLys{G}++
AAGTTCATCACATGCACATGCGTAAGAAA{G}gt
>> {ly}IleAsnThrLeuIleAsnIleMetSerArgLeuGlyGlnAspAspProTh
{||}||||||||||||||||||||||||||||||||||||||||||||||||||
++{ly}IleAsnThrLeuIleAsnIleMetSerArgLeuGlyGlnAspAspProTh
ag{GA}ATTAACACCTTAATAAATATTATGTCACGCCTTGGACAAGATGACCCAAC
rProSer{Ar} >>>> Target Intron 19 >>>> {g}IleAsnHisAsnGl
|||||||{||} 13969 bp {|}||||||||||||||
rProSer{Ar}++ ++{g}IleAsnHisAsnGl
TCCTTCA{AG}gt ag{G}ATTAATCACAATGA
uArgLeuGluPheLeuGlyAspAlaValValGluPheLeuThr{Se} >>>> Targ
|||||||||||||||||||||||||||||||||||||||||||{||}
uArgLeuGluPheLeuGlyAspAlaValValGluPheLeuThr{Se}++
AAGACTGGAGTTCCTGGGTGATGCTGTGGTTGAATTTCTGACC{AG}gt
et Intron 20 >>>> {r}ValHisLeuTyrTyrLeuPheProSerLeuGluGlu
6555 bp {|}||||||||||||||||||||||||||||||||||||
++{r}ValHisLeuTyrTyrLeuPheProSerLeuGluGlu
ag{T}GTCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAA
GlyGlyLeuAlaThrTyrArgThrAlaIleValGlnAsnGlnHisLeuAlaMetLeuA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GlyGlyLeuAlaThrTyrArgThrAlaIleValGlnAsnGlnHisLeuAlaMetLeuA
GGAGGATTAGCAACCTACCGGACTGCCATTGTTCAGAATCAGCACCTTGCCATGCTAG
laLys >>>> Target Intron 21 >>>> LysLeuGluLeuAspArgPheMe
||||| 6832 bp |||||||||||||||||||||||
laLys++ ++LysLeuGluLeuAspArgPheMe
CAAAGgt agAAACTTGAACTGGATCGATTTAT
tLeuTyrAlaHisGlyProAspLeuCysArgGluSerAspLeuArgHisAlaMetAla
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tLeuTyrAlaHisGlyProAspLeuCysArgGluSerAspLeuArgHisAlaMetAla
GCTATACGCTCATGGGCCTGACCTTTGTAGAGAATCGGACCTTCGACATGCAATGGCT
AsnCysPheGluAlaLeuIle{G} >>>> Target Intron 22 >>>> {ly}
|||||||||||||||||||||{|} 3160 bp {||}
AsnCysPheGluAlaLeuIle{G}++ ++{ly}
AATTGTTTTGAAGCATTAATA{G}gt ag{GA}
AlaValTyrLeuGluGlySerLeuGluGluAlaLysGlnLeuPheGlyArgLeuLeuP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AlaValTyrLeuGluGlySerLeuGluGluAlaLysGlnLeuPheGlyArgLeuLeuP
GCTGTTTACTTGGAGGGAAGCCTGGAGGAAGCCAAGCAGCTATTTGGACGCTTACTCT
heAsnAspPro >>>> Target Intron 23 >>>> AspLeuArgGluValTr
||||||||||| 5816 bp |||||||||||||||||
heAsnAspPro++ ++AspLeuArgGluValTr
TTAATGATCCGgt agGACCTGCGCGAAGTCTG
pLeuAsnTyrProLeuHisProLeuGln >>>> Target Intron 24 >>>>
|||||||||||||||||||||||||||| 1564 bp
pLeuAsnTyrProLeuHisProLeuGln++ ++
GCTCAATTATCCTCTCCACCCACTCCAAgt ag
LeuGlnGluProAsnThrAspArgGlnLeuIleGluThrSerProValLeuGlnLysL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LeuGlnGluProAsnThrAspArgGlnLeuIleGluThrSerProValLeuGlnLysL
CTACAAGAACCAAATACTGATCGACAACTTATTGAGACTTCTCCAGTTCTGCAGAAAC
euThrGluPheGluGluAlaIleGlyValIlePheThrHisValArgLeuLeuAlaAr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
euThrGluPheGluGluAlaIleGlyValIlePheThrHisValArgLeuLeuAlaAr
TTACTGAGTTCGAAGAAGCAATTGGAGTGATTTTTACTCATGTTCGACTTCTGGCAAG
gAlaPheThrLeuArgThrValGlyPheAsnHisLeuThr{Le} >>>> Target
||||||||||||||||||||||||||||||||||||||||{||} 10
gAlaPheThrLeuArgThrValGlyPheAsnHisLeuThr{Le}++
GGCATTCACTTTGAGGACTGTGGGATTTAACCATCTGACC{TT}gt
Intron 25 >>>> {u}GlyHisAsnGlnArgMetGluPheLeuGlyAspSerIle
35 bp {|}|||||||||||||||||||||||||||||||||||||||
++{u}GlyHisAsnGlnArgMetGluPheLeuGlyAspSerIle
ag{A}GGCCACAACCAGAGGATGGAATTCCTAGGTGACTCCATA
MetGlnLeuValAlaThrGluTyrLeuPheIleHisPheProAspHisHisGluGlyH
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MetGlnLeuValAlaThrGluTyrLeuPheIleHisPheProAspHisHisGluGlyH
ATGCAGCTGGTAGCCACAGAGTACTTATTTATTCATTTCCCAGATCATCATGAAGGAC
isLeuThr >>>> Target Intron 26 >>>> LeuLeuArgSerSerLeuVa
|||||||| 14001 bp ||||||||||||||||||||
isLeuThr++ ++LeuLeuArgSerSerLeuVa
ACTTAACTgt agTTGTTGCGAAGCTCTTTGGT
lAsnAsnArgThrGlnAlaLysValAlaGluGluLeuGlyMetGlnGluTyrAlaIle
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lAsnAsnArgThrGlnAlaLysValAlaGluGluLeuGlyMetGlnGluTyrAlaIle
GAATAACAGGACTCAAGCCAAGGTAGCAGAGGAGCTGGGCATGCAGGAATATGCCATA
ThrAsnAspLysThrLysArgProValAlaLeuArgThrLysThrLeuAlaAspLeuL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ThrAsnAspLysThrLysArgProValAlaLeuArgThrLysThrLeuAlaAspLeuL
ACGAACGACAAGACCAAGAGACCCGTGGCCCTTCGGACCAAGACCTTGGCGGACCTCT
euGlu{S} >>>> Target Intron 27 >>>> {er}PheIleAlaAlaLeuT
|||||{|} 1428 bp {||}||||||||||||||||
euGlu{S}++ ++{er}PheIleAlaAlaLeuT
TGGAA{T}gt ag{CG}TTTATTGCAGCATTGT
yrIleAspLysAspLeuGluTyrValHisThrPheMetAsnValCysPhePheProAr
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yrIleAspLysAspLeuGluTyrValHisThrPheMetAsnValCysPhePheProAr
ACATTGATAAGGATTTGGAATATGTTCATACTTTCATGAATGTCTGCTTCTTTCCACG
gLeuLys >>>> Target Intron 28 >>>> GluPheIleLeuAsnGlnAsp
||||||| 89 bp |||||||||||||||||||||
gLeuLys++ ++GluPheIleLeuAsnGlnAsp
ATTAAAAgt agGAGTTCATTTTGAATCAGGAT
TrpAsnAspProLysSerGlnLeuGlnGlnCysCysLeuThrLeuArgThrGluGlyL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TrpAsnAspProLysSerGlnLeuGlnGlnCysCysLeuThrLeuArgThrGluGlyL
TGGAATGACCCCAAATCCCAGCTGCAGCAGTGTTGCCTGACACTGAGGACAGAAGGCA
ysGluProAspIleProLeuTyr{Ly} >>>> Target Intron 29 >>>> {
|||||||||||||||||||||||{||} 2486 bp {
ysGluProAspIleProLeuTyr{Ly}++ ++{
AAGAGCCAGATATTCCTCTGTAC{AA}gt ag{
s}ThrLeuGlnThrValGlyProSerHisAlaArgThrTyrThrValAlaValTyrPh
|}||||||||||||||||||||||||||||||||||||||||||||||||||||||||
s}ThrLeuGlnThrValGlyProSerHisAlaArgThrTyrThrValAlaValTyrPh
G}ACTCTGCAGACCGTGGGCCCGTCCCATGCTAGAACTTACACTGTGGCTGTGTATTT
eLysGlyGluArgIleGlyCysGlyLysGlyPro{Se} >>>> Target Intron
||||||||||||||||||||||||||||||||||{||} 575 bp
eLysGlyGluArgIleGlyCysGlyLysGlyPro{Se}++
CAAGGGAGAAAGAATAGGCTGTGGGAAAGGACCA{AG}gt
30 >>>> {r}IleGlnGlnAlaGluMetGlyAlaAlaMetAspAlaLeuGluLys
{|}|||||||||||||||||||||||||||||||||||||||||||||
++{r}IleGlnGlnAlaGluMetGlyAlaAlaMetAspAlaLeuGluLys
ag{C}ATTCAGCAAGCAGAAATGGGAGCTGCAATGGATGCACTTGAAAAA
{T} >>>> Target Intron 31 >>>> {yr}AsnPheProGlnMetAlaHis
{|} 5109 bp {||}|||||||||||||||||||||
{T}++ ++{yr}AsnPheProGlnMetAlaHis
{T}gt ag{AT}AACTTTCCCCAGATGGCCCAT
GlnLysArgPheIleGluArgLysTyrArgGlnGluLeuLysGluMetArgTrpGluA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GlnLysArgPheIleGluArgLysTyrArgGlnGluLeuLysGluMetArgTrpGluA
CAGAAGCGGTTCATTGAACGGAAATACAGACAGGAGTTGAAGGAGATGAGGTGGGAAA
rgGluHisGlnGluArgGluProAspGluThrGluAspIleLysLys
|||||||||||||||||||||||||||||||||||||| ||||||
rgGluHisGlnGluArgGluProAspGluThrGluAspMetLysLys
GAGAGCATCAAGAGAGAGAGCCTGATGAGACCGAGGACATGAAGAAG
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