Basic information |
Official Symbol | CDK11A |
Description | cyclin-dependent kinase 11A |
Other Aliases | RP1-283E3.2, CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE, p58GTA |
Other Description | PITSLRE B; PITSLRE protein kinase beta; PITSLRE serine/threonine-protein kinase CDC2L2; cell division cycle 2-like 2 (PITSLRE proteins); cell division cycle 2-like protein kinase 2; cell division protein kinase 11A; galactosyltransferase-associated protein kinase p58/GTA |
Mutation type | premature termination 252:Q->TAG |
Location | Scaffold143584_1:9565740 9532640 - |
Wiki | Wikipedia GeneCard |
Sequence |
CDK11A |
ATGGGTGATGAAAAGGACTCTTGGAAAGTGAAAACTTTAGATGAAATTCT TCAGGAAAAGAAGCGAAGAAAGGAACAAGAGGAGAAAGCAGAGATAAAAC GCTTAAAAAATTCTGATGACAGGGATTCCAAGCGGGATTCCCTTGAAGAG GGGGAGCTGAGAGATCACCGCATGGAGATCACAATAAGGAACTCTCCATA TAGAAGGGAGGACTCCATGGAAGATAGAGGAGAGGAAGATGATTCTCTGG CTATCAAACCACCCCAGCAAATGTCTCGGAAAGAAAAAGCTCATCACAGG AAAGACGAGAAGAGAAAAGAGAAACGAAAGCACGCCAGAGTGAAAGAAAA AGAAAGAGAACATGAACGTCGGAAACGACATCGAGAAGAACAAGATAAAG CTCGCCGGGAATGGGAAAGACAGAAGAGAAGAGAGATGGCAAGAGAACAT TCCAGGAGAGAGAGGGACCGCTTGGAGCAGTTAGAGAGGAAGCGGGAGCG AGAGCGCAAGCTGCGGGAACAGCAGAAAGAGCAGCGGGAACAGAAGGAGC GGGAGCGGAGGGCTGAGGAACGACGCAAAGAGCGTGAGGCCCGAAGGGAA GTTTCTGCTCATCACCGAACACTGAGAGAGGACTATGGTGATAAGGTGAA AGCAAGCCACTGGAGTCGCAGTCCACTGCGGCCGCCACGGGAGCGGTTTG AGCTAGGAGACGGCCGGAAACCAGGTGAGGTCAGGCCAGCATCTGCTTGG AGACCAACATAGTTGAAAGAAGAGAAGATGGAAGAGAGAGACCTGCTGTC CGACTTACAGGATATCAGCGACAGCGAGAGGAAAACCAGCTCAGCCGAGT CCTCGTCAGCGGAGTCAGGGTCAGGTTCTGAAGAGGAGGAGGAAGAAGAG GAGGAGGAGGAAGAGGAGGGGAGCACCAGTGAAGAATCAGAGGAGGAGGA GGAGGAGGAGGAGGAGGAAGAGGAGGAGGAGACAGGGAGCAACTCCGAGG AGGCATCAGAACAGTCGGCTGAAGAAGTGAGTGAGGAAGAAATGAGTGAG GATGAAGAGCGAGAGAGTGAGAACCACATCCTGGTTGTTCCAGAGTCACG ATTTGACCGAGATTCTGGGGAAAGCGAAGAAGGGGAGGAAGAAGTGGGTG AGGGGACCCCTCAGAGCAGCGCCCTCACCGAAGGAGACTACGTGCCTGAC TCCCCAGCCTTGTCTCCCATCGAGCTCAAGCAGGAGCTGCCCAAGTACCT GCCGGCCCTGCAGGGCTGCCGGAGTGTGGAGGAGTTCCAGTGCCTGAACA GGATCGAGGAGGGCACATATGGGGTGGTCTACAGGGCAAAAGACAAGAAA ACAGATGAAATTGTGGCTTTGAAGCGGTTGAAAATGGAGAAGGAAAAGGA GGGTTTTCCCATCACATCACTGAGGGAGATCAACACCATCCTCAAGGCCC AGCACCCCAACATTGTAACAGTCAGAGAAATTGTCGTGGGCAGCAACATG GATAAGATCTACATTGTGATGAATTATGTAGAACACGACCTCAAGAGCCT AATGGAGACGATGAAGCAGCCCTTTCTGCCAGGAGAGGTGAAGACCCTGA TGATCCAGCTGCTGCGGGGAGTGAAGCACCTGCATGACAACTGGATCCTG CACCGAGACCTCAAGACTTCCAACCTGCTACTGAGCCATGCTGGCATTCT CAAGGTAGGTGACTTTGGGCTGGCTCGAGAGTACGGGTCCCCCCTGAAGG CCTATACCCCAGTCGTGGTGACTCTCTGGTACCGTGCCCCAGAGCTGCTT TTGGGTGCTAAGGAATACTCCACAGCTGTGGACATGTGGTCAGTAGGCTG CATCTTTGGGGAACTGCTGACTCAGAAGCCTCTGTTCCCTGGGAAGTCAG AAATTGATCAGATCAACAAAGTGTTTAAGGACCTGGGGACCCCTAGTGAG AAAATCTGGCCTGGCTACAATGACCTCCCGGCAGTCAAGAAAATGACCTT CAGCGAGTATCCTTACAACAACCTGCGCAAGCGCTTTGGGGCCTTGCTGT CAGACCAGGGCTTTGATCTCATGAACAAGTTTCTGACCTACTTCCCTGGG AGGAGGATCAACGCAGAAGATGGCCTCAAGCATGAGTATTTCCGTGAGAC ACCCCTTCCCATTGACCCCTCGATGTTCCCCACATGGCCAGCCAAGAGTG AGCAACAAAGAGTGAAACGAGGCACCAGCCCACGGCCCCCAGAGGGTGGC CTGGGCTACAGCCAGCTGGGTGACGATGACCTGAAGGAGACCGGCTTCCA CCTCACCACCACCAACCAGGGGGCCTCAGCTGCAGGCCCCGGCTTCAGCC TCAAGTTC |
Alignment |
Align specie | Pep length | Pep align begin | Pep align end | Mutaion type and postion |
Human | 783 | 1 | 783 | Premature termination 252:Q->TAG |
Instructions: *** -> premature termination codon; # -> frame shift Alignment: Human pep sequence ---> |||||||||||||||||||||| Treeshrew pep sequence ---> Treeshrew cds sequence ---> MetGlyAspGluLysAspSerTrpLysValLysThrLeuAspGluIleLeuGlnGluLys |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| MetGlyAspGluLysAspSerTrpLysValLysThrLeuAspGluIleLeuGlnGluLys ATGGGTGATGAAAAGGACTCTTGGAAAGTGAAAACTTTAGATGAAATTCTTCAGGAAAAG LysArgArgLysGluGlnGluGluLysAlaGluIleLysArgLeuLysAsn >>>> Ta ||||||||||||||||||||||||||||||||||||||||||||||||||| LysArgArgLysGluGlnGluGluLysAlaGluIleLysArgLeuLysAsn++ AAGCGAAGAAAGGAACAAGAGGAGAAAGCAGAGATAAAACGCTTAAAAAATgt rget Intron 1 >>>> SerAspAspArgAspSerLysArgAspSerLeuGluGluG 965 bp |||||||||||||||||||||||||||||||||||||||| ++SerAspAspArgAspSerLysArgAspSerLeuGluGluG agTCTGATGACAGGGATTCCAAGCGGGATTCCCTTGAAGAGG lyGluLeuArgAspHisCysMetGluIleThrIleArgAsnSerProTyrArgArgGluA ||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| lyGluLeuArgAspHisArgMetGluIleThrIleArgAsnSerProTyrArgArgGluA GGGAGCTGAGAGATCACCGCATGGAGATCACAATAAGGAACTCTCCATATAGAAGGGAGG spSerMetGluAsp{Ar} >>>> Target Intron 2 >>>> {g}GlyGluGluA ||||||||||||||{||} 2481 bp {|}|||||||||| spSerMetGluAsp{Ar}++ ++{g}GlyGluGluA ACTCCATGGAAGAT{AG}gt ag{A}GGAGAGGAAG spAspSerLeuAlaIleLysProProGlnGlnMetSerArgLysGluLysValHisHisA |||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| spAspSerLeuAlaIleLysProProGlnGlnMetSerArgLysGluLysAlaHisHisA ATGATTCTCTGGCTATCAAACCACCCCAGCAAATGTCTCGGAAAGAAAAAGCTCATCACA rgLysAspGluLysArgLysGluLys{T} >>>> Target Intron 3 >>>> {r ||||||||||||||||||||||||||{ } 4898 bp { rgLysAspGluLysArgLysGluLys{A}++ ++{r GGAAAGACGAGAAGAGAAAAGAGAAA{C}gt ag{G p}LysHisAlaArgVal<-><->LysGluArgGluHisGluArgArgLysArgHisArgG }||||||||||||||| ||||||||||||||||||||||||||||||||||||| g}LysHisAlaArgValLysGluLysGluArgGluHisGluArgArgLysArgHisArgG A}AAGCACGCCAGAGTGAAAGAAAAAGAAAGAGAACATGAACGTCGGAAACGACATCGAG luGluGlnAspLysAlaArgArgGluTrpGluArgGlnLysArgArgGluMetAlaArgG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| luGluGlnAspLysAlaArgArgGluTrpGluArgGlnLysArgArgGluMetAlaArgG AAGAACAAGATAAAGCTCGCCGGGAATGGGAAAGACAGAAGAGAAGAGAGATGGCAAGAG luHisSerArgArgGlu{Ar} >>>> Target Intron 4 >>>> {g}AspArgL |||||||||||||||||{||} 12835 bp {|}||||||| luHisSerArgArgGlu{Ar}++ ++{g}AspArgL AACATTCCAGGAGAGAG{AG}gt ag{G}GACCGCT euGluGlnLeuGluArgLysArgGluArgGluArgLysMetArgGluGlnGlnLysGluG |||||||||||||||||||||||||||||||||||||| ||||||||||||||||||| euGluGlnLeuGluArgLysArgGluArgGluArgLysLeuArgGluGlnGlnLysGluG TGGAGCAGTTAGAGAGGAAGCGGGAGCGAGAGCGCAAGCTGCGGGAACAGCAGAAAGAGC lnArgGluGlnLysGluArgGluArgArgAlaGluGluArgArgLysGluArgGluAlaA |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| lnArgGluGlnLysGluArgGluArgArgAlaGluGluArgArgLysGluArgGluAlaA AGCGGGAACAGAAGGAGCGGGAGCGGAGGGCTGAGGAACGACGCAAAGAGCGTGAGGCCC rgArgGlu{V} >>>> Target Intron 5 >>>> {al}SerAlaHisHisArgT ||||||||{|} 3517 bp {||}|||||||||||||||| rgArgGlu{V}++ ++{al}SerAlaHisHisArgT GAAGGGAA{G}gt ag{TT}TCTGCTCATCACCGAA hrMetArgGluAspTyrSerAspLysValLysAlaSerHisTrpSerArgSerProProA || |||||||||||| |||||||||||||||||||||||||||||||||||| | hrLeuArgGluAspTyrGlyAspLysValLysAlaSerHisTrpSerArgSerProLeuA CACTGAGAGAGGACTATGGTGATAAGGTGAAAGCAAGCCACTGGAGTCGCAGTCCACTGC rgProProArgGluArgPheGluLeuGlyAspGlyArgLysProGlyGluAlaArgProA |||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| rgProProArgGluArgPheGluLeuGlyAspGlyArgLysProGlyGluValArgProA GGCCGCCACGGGAGCGGTTTGAGCTAGGAGACGGCCGGAAACCAGGTGAGGTCAGGCCAG laProAlaGlnLysProAlaGln{L} >>>> Target Intron 6 >>>> {eu}L || ||| ||| {|} 363 bp {||}| laSerAlaTrpArgProThr***{L}++ ++{eu}L CATCTGCTTGGAGACCAACATAG{T}gt ag{TG}A ysGluGluLysMetGluGluArgAspLeuLeuSerAspLeuGlnAspIleSerAspSerG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| ysGluGluLysMetGluGluArgAspLeuLeuSerAspLeuGlnAspIleSerAspSerG AAGAAGAGAAGATGGAAGAGAGAGACCTGCTGTCCGACTTACAGGATATCAGCGACAGCG luArgLysThrSerSerAlaGluSerSerSer{A} >>>> Target Intron 7 >> ||||||||||||||||||||||||||||||||{|} 85 bp luArgLysThrSerSerAlaGluSerSerSer{A}++ AGAGGAAAACCAGCTCAGCCGAGTCCTCGTCA{G}gt >> {la}GluSerGlySerGlySerGluGluGluGluGluGluGluGluGluGluGluG {||}|||||||||||||||||||||||||||||||||||||||||||||||||||| ++{la}GluSerGlySerGlySerGluGluGluGluGluGluGluGluGluGluGluG ag{CG}GAGTCAGGGTCAGGTTCTGAAGAGGAGGAGGAAGAAGAGGAGGAGGAGGAAG luGluGlySerThrSerGluGluSer<->GluGluGluGluGluGluGluGluGluGluG |||||||||||||||||||||||||| ||||||||||||||||||||||||||||||| luGluGlySerThrSerGluGluSerGluGluGluGluGluGluGluGluGluGluGluG AGGAGGGGAGCACCAGTGAAGAATCAGAGGAGGAGGAGGAGGAGGAGGAGGAGGAAGAGG luGluGluThrGlySerAsnSerGluGluAlaSerGluGlnSerAla{G} >>>> Tar |||||||||||||||||||||||||||||||||||||||||||||||{|} luGluGluThrGlySerAsnSerGluGluAlaSerGluGlnSerAla{G}++ AGGAGGAGACAGGGAGCAACTCCGAGGAGGCATCAGAACAGTCGGCT{G}gt get Intron 8 >>>> {lu}GluValSerGluGluGluMetSerGluAspGluGluA 908 bp {||}||||||||||||||||||||||||||||||||||||| ++{lu}GluValSerGluGluGluMetSerGluAspGluGluA ag{AA}GAAGTGAGTGAGGAAGAAATGAGTGAGGATGAAGAGC rgGluAsnGluAsnHisLeuLeuVal{V} >>>> Target Intron 9 >>>> {a ||||| ||||||||| ||||||{|} 1442 bp {| rgGluSerGluAsnHisIleLeuVal{V}++ ++{a GAGAGAGTGAGAACCACATCCTGGTT{G}gt ag{T l}ProGluSerArgPheAspArgAspSerGlyGluSerGluGluAlaGluGluGluValG |}|||||||||||||||||||||||||||||||||||||||||| ||||||||||||| l}ProGluSerArgPheAspArgAspSerGlyGluSerGluGluGlyGluGluGluValG T}CCAGAGTCACGATTTGACCGAGATTCTGGGGAAAGCGAAGAAGGGGAGGAAGAAGTGG lyGluGlyThrProGlnSerSerAlaLeuThrGluGlyAspTyrValProAspSerProA |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| lyGluGlyThrProGlnSerSerAlaLeuThrGluGlyAspTyrValProAspSerProA GTGAGGGGACCCCTCAGAGCAGCGCCCTCACCGAAGGAGACTACGTGCCTGACTCCCCAG laLeuLeuProIleGluLeuLysGlnGluLeuProLysTyrLeuProAlaLeuGln >> ||||| |||||||||||||||||||||||||||||||||||||||||||||||| laLeuSerProIleGluLeuLysGlnGluLeuProLysTyrLeuProAlaLeuGln++ CCTTGTCTCCCATCGAGCTCAAGCAGGAGCTGCCCAAGTACCTGCCGGCCCTGCAGgt >> Target Intron 10 >>>> GlyCysArgSerValGluGluPheGlnCysLeuA 989 bp |||||||||||||||||||||||||||||||||| ++GlyCysArgSerValGluGluPheGlnCysLeuA agGGCTGCCGGAGTGTGGAGGAGTTCCAGTGCCTGA snArgIleGluGluGlyThrTyrGlyValValTyrArgAlaLysAspLysLysThr{A} ||||||||||||||||||||||||||||||||||||||||||||||||||||||||{|} snArgIleGluGluGlyThrTyrGlyValValTyrArgAlaLysAspLysLysThr{A}+ ACAGGATCGAGGAGGGCACATATGGGGTGGTCTACAGGGCAAAAGACAAGAAAACA{G}g >>>> Target Intron 11 >>>> {sp}GluIleValAlaLeuLysArgLeuLys 962 bp {||}||||||||||||||||||||||||||| + ++{sp}GluIleValAlaLeuLysArgLeuLys t ag{AT}GAAATTGTGGCTTTGAAGCGGTTGAAA MetGluLysGluLysGluGlyPheProIleThrSerLeuArgGluIleAsnThrIleLeu |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| MetGluLysGluLysGluGlyPheProIleThrSerLeuArgGluIleAsnThrIleLeu ATGGAGAAGGAAAAGGAGGGTTTTCCCATCACATCACTGAGGGAGATCAACACCATCCTC LysAlaGlnHisProAsnIleValThrValArg >>>> Target Intron 12 >>> ||||||||||||||||||||||||||||||||| 252 bp LysAlaGlnHisProAsnIleValThrValArg++ AAGGCCCAGCACCCCAACATTGTAACAGTCAGAgt > GluIleValValGlySerAsnMetAspLysIleTyrIleValMetAsnTyrValGlu ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| ++GluIleValValGlySerAsnMetAspLysIleTyrIleValMetAsnTyrValGlu agGAAATTGTCGTGGGCAGCAACATGGATAAGATCTACATTGTGATGAATTATGTAGAA HisAspLeuLysSerLeuMetGluThrMetLysGlnProPheLeuPro{G} >>>> Ta ||||||||||||||||||||||||||||||||||||||||||||||||{|} HisAspLeuLysSerLeuMetGluThrMetLysGlnProPheLeuPro{G}++ CACGACCTCAAGAGCCTAATGGAGACGATGAAGCAGCCCTTTCTGCCA{G}gt rget Intron 13 >>>> {ly}GluValLysThrLeuMetIleGlnLeuLeuArgGl 274 bp {||}||||||||||||||||||||||||||||||||||| ++{ly}GluValLysThrLeuMetIleGlnLeuLeuArgGl ag{GA}GAGGTGAAGACCCTGATGATCCAGCTGCTGCGGGG yValLysHisLeuHisAspAsnTrpIleLeuHisArgAspLeuLysThrSerAsnLeuLe |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| yValLysHisLeuHisAspAsnTrpIleLeuHisArgAspLeuLysThrSerAsnLeuLe AGTGAAGCACCTGCATGACAACTGGATCCTGCACCGAGACCTCAAGACTTCCAACCTGCT uLeuSerHisAlaGlyIleLeuLys >>>> Target Intron 14 >>>> ValGl ||||||||||||||||||||||||| 74 bp ||||| uLeuSerHisAlaGlyIleLeuLys++ ++ValGl ACTGAGCCATGCTGGCATTCTCAAGgt agGTAGG yAspPheGlyLeuAlaArgGluTyrGlySerProLeuLysAlaTyrThrProValValVa |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| yAspPheGlyLeuAlaArgGluTyrGlySerProLeuLysAlaTyrThrProValValVa TGACTTTGGGCTGGCTCGAGAGTACGGGTCCCCCCTGAAGGCCTATACCCCAGTCGTGGT lThrGlnTrpTyrArgAlaProGluLeuLeuLeuGlyAlaLys >>>> Target Int |||| |||||||||||||||||||||||||||||||||||| 122 b lThrLeuTrpTyrArgAlaProGluLeuLeuLeuGlyAlaLys++ GACTCTCTGGTACCGTGCCCCAGAGCTGCTTTTGGGTGCTAAGgt ron 15 >>>> GluTyrSerThrAlaValAspMetTrpSerValGlyCysIlePheGl p ||||||||||||||||||||||||||||||||||||||||||||||| ++GluTyrSerThrAlaValAspMetTrpSerValGlyCysIlePheGl agGAATACTCCACAGCTGTGGACATGTGGTCAGTAGGCTGCATCTTTGG yGluLeuLeuThrGlnLysProLeuPheProGlyAsnSerGluIleAspGlnIleAsnLy |||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| yGluLeuLeuThrGlnLysProLeuPheProGlyLysSerGluIleAspGlnIleAsnLy GGAACTGCTGACTCAGAAGCCTCTGTTCCCTGGGAAGTCAGAAATTGATCAGATCAACAA sValPheLys >>>> Target Intron 16 >>>> GluLeuGlyThrProSerGl |||||||||| 331 bp ||||||||||||||||| sValPheLys++ ++AspLeuGlyThrProSerGl AGTGTTTAAGgt agGACCTGGGGACCCCTAGTGA uLysIleTrpProGlyTyrSerGluLeuProValValLysLysMetThrPheSerGluHi ||||||||||||||||||| |||||| |||||||||||||||||||||||| uLysIleTrpProGlyTyrAsnAspLeuProAlaValLysLysMetThrPheSerGluTy GAAAATCTGGCCTGGCTACAATGACCTCCCGGCAGTCAAGAAAATGACCTTCAGCGAGTA sProTyrAsnAsnLeuArgLysArgPheGlyAlaLeuLeuSerAspGlnGlyPheAspLe ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| rProTyrAsnAsnLeuArgLysArgPheGlyAlaLeuLeuSerAspGlnGlyPheAspLe TCCTTACAACAACCTGCGCAAGCGCTTTGGGGCCTTGCTGTCAGACCAGGGCTTTGATCT uMetAsn{Ly} >>>> Target Intron 17 >>>> {s}PheLeuThrTyrPheP |||||||{||} 168 bp {|}|||||||||||||||| uMetAsn{Ly}++ ++{s}PheLeuThrTyrPheP CATGAAC{AA}gt ag{G}TTTCTGACCTACTTCC roGlyArgArgIleSerAlaGluAspGlyLeuLysHisGluTyrPheArgGluThrProL |||||||||||||| ||||||||||||||||||||||||||||||||||||||||||| roGlyArgArgIleAsnAlaGluAspGlyLeuLysHisGluTyrPheArgGluThrProL CTGGGAGGAGGATCAACGCAGAAGATGGCCTCAAGCATGAGTATTTCCGTGAGACACCCC euProIleAspProSerMetPheProThrTrpProAlaLysSerGluGlnGlnArgValL |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| euProIleAspProSerMetPheProThrTrpProAlaLysSerGluGlnGlnArgValL TTCCCATTGACCCCTCGATGTTCCCCACATGGCCAGCCAAGAGTGAGCAACAAAGAGTGA ysArgGlyThrSerProArgProProGluGlyGlyLeuGlyTyrSerGlnLeu >>>> ||||||||||||||||||||||||||||||||||||||||||||||||||||| ysArgGlyThrSerProArgProProGluGlyGlyLeuGlyTyrSerGlnLeu++ AACGAGGCACCAGCCCACGGCCCCCAGAGGGTGGCCTGGGCTACAGCCAGCTGgt Target Intron 18 >>>> GlyAspAspAspLeuLysGluThrGlyPheHisLeuT 77 bp ||||||||||||||||||||||||||||||||||||| ++GlyAspAspAspLeuLysGluThrGlyPheHisLeuT agGGTGACGATGACCTGAAGGAGACCGGCTTCCACCTCA hrThrThrAsnGlnGlyAlaSerAlaAlaGlyProGlyPheSerLeuLysPhe ||||||||||||||||||||||||||||||||||||||||||||||||||||| hrThrThrAsnGlnGlyAlaSerAlaAlaGlyProGlyPheSerLeuLysPhe CCACCACCAACCAGGGGGCCTCAGCTGCAGGCCCCGGCTTCAGCCTCAAGTTC // |